Menningen R, Günther M, Bönninghoff N, Stahlknecht C D, Kubitza I, Kusche J
Agents Actions. 1986 Apr;18(1-2):38-40. doi: 10.1007/BF01987976.
In the operative treatment of appendicitis the so called negative appendectomy is an important issue because of its increased morbidity. From the hypothesis that the intestinal diamine oxidase activity is a suitable marker of mucosal integrity, the distribution pattern of the enzyme in appendices histologically classified as inflamed or not inflamed was studied. Histologically apparent inflammation of the appendix was connected with a significant reduction of diamine oxidase activity. The determination of this enzymic activity may be a simple and sensitive test for mucosal inflammation of the appendix even at a very early state. This could reduce the rate of negative appendectomies and influence thereby risk-cost-benefit calculations.
在阑尾炎的手术治疗中，所谓的阴性阑尾切除术是一个重要问题，因为其发病率有所增加。基于肠二胺氧化酶活性是黏膜完整性合适标志物的假设，研究了该酶在组织学上分类为发炎或未发炎阑尾中的分布模式。阑尾组织学上明显的炎症与二胺氧化酶活性的显著降低有关。即使在非常早期的状态下，测定这种酶活性也可能是一种用于阑尾黏膜炎症的简单而敏感的检测方法。这可以降低阴性阑尾切除术的发生率，从而影响风险 - 成本 - 效益计算。
