Forget P, Saye Z, Van Cutsem J L, Dandrifosse G
Pediatr Res. 1985 Jan;19(1):26-8. doi: 10.1203/00006450-198501000-00008.
Serum diamine oxidase (DAO) activities were measured in 20 control patients and in 24 patients with gastroenteritis. Results (mean +/- SE) were as follows: 1) control patients (n = 20), 36.2 +/- 5.7 pmol h-1 ml-1; 2) gastroenteritis (acute phase) (n = 11), 31 +/- 4.9 pmol h-1 ml-1; 3) gastroenteritis (healing phase) (n = 21), 18 +/- 1.9 pmol h-1 ml-1. Patients with gastroenteritis in the healing phase had significantly lower DAO values when compared to control patients (p less than 0.001) and to gastroenteritis patients in the acute phase (p less than 0.05). In eight patients where both acute and healing phase values could be measured, a significant decrease between acute and healing phase was found (p less than 0.001). Patients with severe gastroenteritis tended to have lower DAO activity values than patients with moderate gastroenteritis (p = 0.10). Our results support the hypothesis that serum DAO activity is a marker of the total mass of functional enterocytes, the decrease of which during gastroenteritis is reflected in a decrease of serum DAO activity values.
在20名对照患者和24名肠胃炎患者中测量了血清二胺氧化酶（DAO）活性。结果（平均值±标准误）如下：1）对照患者（n = 20），36.2±5.7 pmol h-1 ml-1；2）肠胃炎（急性期）（n = 11），31±4.9 pmol h-1 ml-1；3）肠胃炎（愈合期）（n = 21），18±1.9 pmol h-1 ml-1。与对照患者相比（p < 0.001）以及与肠胃炎急性期患者相比（p < 0.05），肠胃炎愈合期患者的DAO值显著更低。在8名可同时测量急性期和愈合期值的患者中，发现急性期和愈合期之间有显著下降（p < 0.001）。重症肠胃炎患者的DAO活性值往往低于中度肠胃炎患者（p = 0.10）。我们的结果支持以下假设：血清DAO活性是功能性肠细胞总量的标志物，肠胃炎期间其降低反映在血清DAO活性值的降低上。
