Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, No 157 Xiwulu,Xincheng District, Xi'an City, Shaanxi Province, China.
Drug Dev Res. 2019 Jun;80(4):453-460. doi: 10.1002/ddr.21517. Epub 2019 Mar 19.
Myocardial infarction (MI) is indicated by the symptoms like sharp chest pain, sweating, palpitations, and nervousness finally leading to heart attack. MI occurs mainly due to the risk factors like smoking, elevated blood pressure, diabetes, hypercholesterolemia, obesity, decreased HDL level, elevated LDL level, hyperlipoproteinemia and aging consequently leads to demandable coronary blood supply, oxidative stress, and acute necrosis of the myocardium. Cardioprotective potential of the phloroglucinol (PG) was assessed by treating isoprenaline hydrochloride (ISO; 85 mg/kg b.w., s.c.) induced MI model in rats. Pretreatment with PG in a dose of 30 mg/kg was done for 28 days and followed by ISO (for MI induction) on 29th and 30th days, exhibited decline in the abnormalities in the ECG patterns, cardiac marker enzymes, enzymic and nonenzymic antioxidants, lipid peroxidation, lipid profiles, and histopathological investigations compared to isoprenaline alone treated group. On the whole, the present investigations elucidate the significance of PG in alleviating the pathological process and appreciably prevent the induction of MI in experimental rats.
心肌梗死（MI）的症状包括剧烈胸痛、出汗、心悸和紧张，最终导致心脏病发作。MI 主要由于以下风险因素引起：吸烟、高血压、糖尿病、高胆固醇血症、肥胖、低 HDL 水平、高 LDL 水平、高脂血症和衰老，从而导致冠状动脉供血不足、氧化应激和心肌急性坏死。通过用盐酸异丙肾上腺素（ISO；85mg/kg b.w.，sc）诱导大鼠 MI 模型来评估间苯三酚（PG）的心脏保护潜力。用 30mg/kg 的 PG 进行预处理 28 天，然后在第 29 天和第 30 天用 ISO（用于诱导 MI），与单独用 ISO 处理的组相比，心电图模式、心脏标志物酶、酶和非酶抗氧化剂、脂质过氧化、脂质谱和组织病理学研究中的异常情况减少。总的来说，目前的研究阐明了 PG 在减轻病理过程中的重要性，并显著防止了实验大鼠 MI 的诱导。
