Medical Faculty, Mashhad University of Medical Sciences, Mashhad, Iran.
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Int Ophthalmol. 2023 Oct;43(10):3615-3621. doi: 10.1007/s10792-023-02770-7. Epub 2023 Jul 2.
In thyroid eye disease (TED), all ocular components and adnexa such as extraocular muscles, orbital adipose tissues, eyelids, and tear glands could be affected. This study aimed to study the orbital biomechanical parameters in patients with TED, in terms of differences with healthy individuals and correlation with clinical findings, using Corvis ST (CST, Oculus Wetzlar).
In this study, 26 consecutive patients with TED were recruited. Demographic data were collected, and patients with TED were assessed for exophthalmos, intraocular pressure, and clinical activity score. Biomechanical response parameters of one randomly-chosen eye of each patient, including whole eye movement length (WEMl) and time (WEMt), were evaluated by the CST, and data were compared between patients and age- and gender-matched healthy controls.
The mean age was 39.88 ± 11.61 years old for patients with TED and 34.38 ± 8.57 years old for the healthy subjects. Nine out of 26 patients with TED and nine of 26 healthy individuals were male. The median duration of thyroid disease was 36 (IQR 54) months and the median duration of thyroid ophthalmopathy was 27 (IQR 27) months. Four out of 26 patients (7.7%) had active disease. The mean WEMl was 206.15 ± 61.58 µm in the TED group and 254.23 ± 64.01 μm in the healthy group, the difference of which was statistically significant (p = 0.008). The median of WEMt was 20.90 (1.15) msec in the TED group and 21.45 (0.93) msec in the healthy group (p < 0.001). Also, the mean of WEMl and WEMt were lower in patients with active disease compared to patients with quiescent disease.
The CST-derived WEMl was significantly smaller in patients with thyroid eye disease compared to normal subjects. The WEMl and WEMt were relatively shorter in the patients with active TED compared to the patients with quiescent TED, although small numbers of patients with active TED limits took a statistically significant conclusion. WEMl and WEMt might be useful in evaluating the compliance of the orbit in patients with TED.
在甲状腺眼病（TED）中，眼外肌、眶内脂肪组织、眼睑和泪腺等所有眼附属器和附件都可能受到影响。本研究旨在使用 Corvis ST（CST，Oculus Wetzlar）研究 TED 患者的眼眶生物力学参数，从与健康个体的差异以及与临床发现的相关性方面进行研究。
本研究纳入了 26 例连续 TED 患者。收集了人口统计学数据，并对 TED 患者进行了眼球突出度、眼压和临床活动评分评估。使用 CST 评估每位患者的一只随机眼的生物力学反应参数，包括全眼运动长度（WEMl）和时间（WEMt），并将患者数据与年龄和性别匹配的健康对照组进行比较。
TED 患者的平均年龄为 39.88 ± 11.61 岁，健康对照组为 34.38 ± 8.57 岁。26 例 TED 患者中有 9 例和 26 例健康个体中有 9 例为男性。甲状腺疾病的中位病程为 36（IQR 54）个月，甲状腺眼病的中位病程为 27（IQR 27）个月。26 例患者中有 4 例（7.7%）为活动期疾病。TED 组的平均 WEMl 为 206.15 ± 61.58 µm，健康对照组为 254.23 ± 64.01 µm，差异具有统计学意义（p = 0.008）。TED 组的 WEMt 中位数为 20.90（1.15）msec，健康对照组为 21.45（0.93）msec（p < 0.001）。此外，与静止性 TED 患者相比，活动期 TED 患者的 WEMl 均值和 WEMt 均值更低。
与正常对照相比，甲状腺眼病患者的 CST 衍生的 WEMl 明显较小。与静止性 TED 患者相比，活动期 TED 患者的 WEMl 和 WEMt 相对较短，尽管活动期 TED 患者数量较少，无法得出统计学上的显著结论。WEMl 和 WEMt 可能有助于评估 TED 患者眼眶的顺应性。
