National Institute of Hygiene and Epidemiology, Hanoi, Vietnam; Vietnam National Cancer Institute, Vietnam National Cancer Hospital, 30 Cau Buou, Hanoi, Vietnam.
The Cancer Prevention and Control Program, University of South Carolina, Columbia, South Carolina, USA.
Nutrition. 2019 Jun;62:140-145. doi: 10.1016/j.nut.2018.12.012. Epub 2019 Jan 2.
Inflammatory potential of diet, as measured by the dietary inflammatory index (DII), has consistently been associated with an increased risk for prostate cancer (PCa). However, data has largely been reported in populations with more proinflammatory dietary patterns, whereas there is high diversity in dietary pattern worldwide. The aim of this study was to assess the association between DII scores and the risk for PCa in Vietnam.
A case-control study of 652 participants (244 incident PCa patients, 64-75 y of age, and 408 controls, frequency matched for age) was conducted in Ho Chi Minh City, Vietnam, from 2013 to 2015. Habitual diet was ascertained using a validated food frequency questionnaire (FFQ), whereas other factors, including demographic and lifestyle characteristics, were assessed via face-to-face interviews. The daily intake of pro- and anti-inflammatory nutrients for each participant was calculated from the FFQ and used to estimate individuals' energy-adjusted DII (E-DII) scores. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression models.
Comparing the middle and highest versus lowest tertile of DII scores, there was an increased risk for overall PCa. The OR and associated 95% CI was 2.63 (1.61-4.37) and 3.35 (2.06-5.53), respectively (P < 0.01). Similar results were found for low-moderate and high-grade PCa. The respective ORs (95% CI) were 3.34 (1.66-7.13) and 5.29 (2.69-11.18), P < 0.001, and 2.51 (1.40-4.63) and 2.57 (1.43-4.73), P 0.006.
A proinflammatory diet was associated with increased risk for PCa among Vietnamese men.
饮食的炎症潜能（通过饮食炎症指数[DII]来衡量）与前列腺癌（PCa）的风险增加密切相关。然而，这些数据主要在具有更多促炎饮食模式的人群中报告，而全球的饮食模式存在高度多样性。本研究旨在评估 DII 评分与越南 PCa 风险之间的关系。
2013 年至 2015 年，在越南胡志明市进行了一项病例对照研究，共纳入 652 名参与者（244 名新发 PCa 患者，年龄 64-75 岁，408 名对照组，年龄匹配）。使用经过验证的食物频率问卷（FFQ）来确定习惯性饮食，通过面对面访谈来评估其他因素，包括人口统计学和生活方式特征。从 FFQ 中计算每个参与者的促炎和抗炎营养素的每日摄入量，并用于估计个体的能量调整 DII（E-DII）评分。使用无条件逻辑回归模型估计多变量调整后的比值比（OR）和 95%置信区间（CI）。
与 DII 评分的中间和最高三分位与最低三分位相比，总体 PCa 的风险增加。OR 和相关的 95%CI 分别为 2.63（1.61-4.37）和 3.35（2.06-5.53）（P<0.01）。对于低中度和高度 PCa 也发现了类似的结果。相应的 OR（95%CI）分别为 3.34（1.66-7.13）和 5.29（2.69-11.18），P<0.001，以及 2.51（1.40-4.63）和 2.57（1.43-4.73），P<0.006。
促炎饮食与越南男性 PCa 的风险增加有关。
