Organic Polymer Laboratory, Centre of Advanced Studies in Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Organic Polymer Laboratory, Centre of Advanced Studies in Chemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, UP, India.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1384-1391. doi: 10.1016/j.msec.2019.02.074. Epub 2019 Feb 21.
A simple approach for preparing self-healable guar gum-graft-acrylic acid (GG-PAA) hydrogel using l-alanine as a cross-linking agent was introduced for the first time. It drastically modifies the mechanical strength of the hydrogel to G' = 90,570 Pa. Thus, a series of guar gum (GG) based hydrogel was synthesized by varying the concentration of l-alanine from 0.4 to 1% w/v. The hydrogel was characterized by different analytical techniques such as FTIR, HRSEM etc. The mechanical strength of the hydrogel was investigated by rheology analysis and it was observed in terms of storage and loss modulus i.e. G' & G'', respectively. Maximum G' & G'' (90,560 Pa & 60,820 Pa) were observed when 1 wt% of l-alanine was used as a cross-linking agent. This GG based hydrogel have shown excellent swelling i.e. up to 3350%, which indicates its porous network. The synthesized hydrogel has been identified as a controlled drug delivery gel, which releases 98% of the highly water-soluble loaded drug in 140 h.
首次介绍了一种使用 l-丙氨酸作为交联剂制备自修复瓜尔胶接枝丙烯酸（GG-PAA）水凝胶的简单方法。它极大地改变了水凝胶的机械强度，达到 G'=90570Pa。因此，通过改变 l-丙氨酸的浓度从 0.4 到 1%w/v，合成了一系列基于瓜尔胶的水凝胶。水凝胶通过傅里叶变换红外光谱（FTIR）、高分辨率扫描电子显微镜（HRSEM）等不同分析技术进行了表征。通过流变学分析研究了水凝胶的机械强度，并分别以储能模量（G'）和损耗模量（G''）表示。当使用 1%wt%的 l-丙氨酸作为交联剂时，观察到最大的 G'和 G''（90560Pa 和 60820Pa）。这种基于瓜尔胶的水凝胶表现出优异的溶胀性，即高达 3350%，这表明其具有多孔网络。合成的水凝胶被鉴定为一种控制药物释放凝胶，可在 140 小时内释放 98%的高水溶性负载药物。
