College of Bioresources and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China.
College of Bioresources and Materials Engineering, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China; National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021. PR China.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:1509-1522. doi: 10.1016/j.msec.2019.02.070. Epub 2019 Feb 19.
Collagen is the most abundant structural protein of connective tissues including skin, tendon, bone and cartilage in mammals. The complicated biosynthesis of nature collagen in vivo, involving numerous intracellular and extracellular steps, causes it to have a multi-hierarchical fibrous architecture. The bioactivity of collagen is mostly depended on its tertiary structure or above. In the past decades, collagen biomaterials have received many attentions in biological applications due to its excellent properties, such as low immunogenicity, biodegradable, biocompatibility, hydrophilicity, easy processing, etc. However, collagen is also suffering from the poor physical and chemical properties (mechanical strength, thermostability, resistance to enzyme and so on). Therefore, the modification of collagen in preparation process is necessary. This review will shed light on the crosslinking methods and the recent advances of collagen-based materials in biomedical applications including skin substitute, bone repair, tendon repair, cartilage repair, neural repair and delivery system.
胶原蛋白是哺乳动物中包括皮肤、肌腱、骨骼和软骨在内的结缔组织中含量最丰富的结构蛋白。天然胶原蛋白在体内的复杂生物合成过程涉及许多细胞内和细胞外步骤，导致其具有多层次的纤维结构。胶原蛋白的生物活性主要取决于其三级结构或以上。在过去的几十年中，由于胶原蛋白具有低免疫原性、可生物降解、生物相容性、亲水性、易于加工等优良特性，其在生物应用中受到了广泛关注。然而，胶原蛋白也存在物理化学性质差（机械强度、热稳定性、抗酶性等）的问题。因此，在制备过程中对胶原蛋白进行修饰是必要的。本文综述了交联方法以及基于胶原蛋白的材料在皮肤替代物、骨修复、肌腱修复、软骨修复、神经修复和递药系统等生物医学应用中的最新进展。
