Departament de Bioquímica i Fisiologia, Secció de Fisiologia - Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain; Institut de Nanociència i Nanotecnologia - IN(2)UB, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain.
Departament de Bioquímica i Fisiologia, Secció de Fisiologia - Facultat de Farmàcia i Ciències de l'Alimentació, Universitat de Barcelona, Avda. Joan XXIII s/n, 08028 Barcelona, Spain.
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:241-247. doi: 10.1016/j.msec.2019.01.088. Epub 2019 Jan 22.
Surface properties like hydrophobicity and morphology of the substrate are essential for cell proliferation affecting its growth, survival and also for its communication with other cells on fabrics. The combination of low surface energy and a specific surface morphology (micro/nano-roughness) leads to significantly less wettable surfaces, known as superhydrophobic characterized by high contact angle above 150° and a very small hysteresis. Such high water repellent coatings feature small area available to be exploited in many applications where interactions with aqueous environment are strongly to be avoided. In this work, the authors have investigated the influence of coating polyester fabric at different degree of hydrophobicity by mixed organic-inorganic coating with moderated to highly water repellence. Depending on the coating composition and structure, the hydrophobicity of the fabric can be finely modulated by an easy-to-prepare method applicable to commercial, low cost fabric substrates providing advanced performance. In vitro experiments have been performed in order to establish the influence of surface modification on adhesion of representative model mammalian cell lines such as 3T3 fibroblasts, HaCaT keratinocytes and HeLa epithelial carcinoma cells. The obtained results suggested that, in addition to the chemistry and morphology of the coating, the characteristics of the substrate are important parameters on the final cell viabilities.
表面特性，如基底的疏水性和形态，对细胞增殖有重要影响，影响其生长、存活，以及与织物上其他细胞的交流。低表面能与特定表面形态（微/纳米粗糙度）的结合导致表面可湿性显著降低，这种表面被称为超疏水，其特征是接触角大于 150°，滞后非常小。这种高拒水涂层的特点是可用面积小，在许多需要强烈避免与水相环境相互作用的应用中具有很大的潜力。在这项工作中，作者通过混合有机-无机涂层来研究不同程度疏水性的聚酯纤维涂层对涂层的影响，这种涂层具有中等至高度的拒水性能。根据涂层的组成和结构，通过一种易于制备的方法可以精细调节织物的疏水性，这种方法适用于商业上低成本的纤维基底，提供了先进的性能。为了建立表面改性对代表性模型哺乳动物细胞系（如 3T3 成纤维细胞、HaCaT 角质形成细胞和 HeLa 上皮癌细胞）黏附的影响，进行了体外实验。结果表明，除了涂层的化学性质和形态外，基底的特性也是最终细胞活力的重要参数。
