a Department of Psychology , Ryerson University , Toronto , Canada.
b Remedy , Toronto , Canada.
J Psychoactive Drugs. 2019 Apr-Jun;51(2):166-173. doi: 10.1080/02791072.2019.1589028. Epub 2019 Mar 19.
Treatments for posttraumatic stress disorder (PTSD) have evolved significantly in the past 35 years. From what was historically viewed as a pervasive, intractable condition have emerged multiple evidence-based intervention options. These treatments, predominantly cognitive behavioral in orientation, provide significant symptom improvement in 50-60% of recipients. The treatment of PTSD with MDMA-assisted psychotherapy using a supportive, non-directive approach has yielded promising results. It is unknown, however, how different therapeutic modalities could impact or improve outcomes. Therefore, to capitalize on the strengths of both approaches, Cognitive Behavioral Conjoint Therapy for PTSD (CBCT) was combined with MDMA in a small pilot trial. The current article provides a case study of one couple involved in the trial, chosen to provide a demographically representative example of the study participants and a case with a severe trauma history, to offer a detailed account of the methodology and choices made to integrate CBCT and MDMA, as well as an account of their experience through the treatment and their treatment gains. This article offers a description of the combination of CBCT for PTSD and MDMA, and demonstrates that it can produce reductions in PTSD symptoms and improvements in relationship satisfaction.
创伤后应激障碍（PTSD）的治疗在过去 35 年中发生了重大变化。从历史上被认为是普遍存在、难以治愈的疾病中，出现了多种基于证据的干预选择。这些治疗方法主要以认知行为为导向，为 50-60%的接受者提供了显著的症状改善。采用支持性、非指导性方法的 MDMA 辅助心理治疗 PTSD 已取得了有希望的结果。然而，目前尚不清楚不同的治疗方式如何影响或改善结果。因此，为了充分利用这两种方法的优势，认知行为联合治疗 PTSD（CBCT）与 MDMA 联合应用于一项小型试点试验中。本文提供了一项参与该试验的夫妻案例研究，选择该案例是为了提供研究参与者的人口统计学代表性示例和具有严重创伤史的案例，详细说明整合 CBCT 和 MDMA 的方法和选择，以及他们在治疗过程中的经历和治疗收益。本文描述了 PTSD 的 CBCT 与 MDMA 的联合应用，并证明它可以减少 PTSD 症状和提高关系满意度。
