Christie J D, Crouse D, Kelada A S, Anis-Ishak E, Smith J H, Kamel I A
Am J Trop Med Hyg. 1986 Jul;35(4):759-64. doi: 10.4269/ajtmh.1986.35.759.
The distribution of S. haematobium eggs in urinary bladders containing tumors and removed at surgery has been studied; the majority of these tumors are well differentiated squamous cell carcinomas. The same three anatomic patterns of egg accumulation described in part I of this series (noncancerous lower urinary tracts) were found in these cancerous bladders, but, in addition, most of the tumors were surrounded by a collar of heavy S. haematobium egg deposition. The egg burdens in these collars were, on the average, twice the average egg burden in the remainder of the urinary bladder. These collars do not seem to be artifacts created by growth of the tumor and subsequent displacement of the adjacent normal tissue, creating a region of heavy egg concentrations; rather, these heavy S. haematobium egg concentrations seem to act as promoters of urothelial carcinogenesis.
对手术切除的含有肿瘤的膀胱中埃及血吸虫卵的分布情况进行了研究；这些肿瘤大多为高分化鳞状细胞癌。在这些癌性膀胱中发现了本系列第一部分（非癌性下尿路）中描述的相同三种虫卵聚集的解剖学模式，但除此之外，大多数肿瘤周围都有一圈密集的埃及血吸虫卵沉积。这些卵环中的虫卵负荷平均是膀胱其余部分平均虫卵负荷的两倍。这些卵环似乎不是肿瘤生长以及随后相邻正常组织移位导致的假象，从而形成虫卵高浓度区域；相反，这些密集的埃及血吸虫卵浓度似乎起到了尿路上皮癌发生促进剂的作用。
