Chen Haixia, Xie Xiaoxiao, Tang Shuming
Haixia Chen, Department of Clinical Laboratory, Shenzhen People's, Hospital the Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong Province 518020, China.
Xiaoxiao Xie, Department of Clinical Laboratory, Shenzhen People's, Hospital the Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong Province 518020, China.
Pak J Med Sci. 2024 Jan-Feb;40(1Part-I):174-178. doi: 10.12669/pjms.40.1.8194.
To identify the association between the changes in intestinal microflora and renal function in patients with chronic renal failure (CRF).
This retrospective case-control study included 50 patients with CRF (study group), admitted to the Clinical Laboratory Department of Shenzhen People's Hospital from March 2021 to May 2022, and 50 healthy individuals (control group). The association between the distribution of intestinal microflora and the glomerular filtration rate (GFR), levels of serum creatinine (SCr), blood urea nitrogen (BUN), and serum cystatin C (CysC) were analyzed.
Intestinal microflora of CRF patients had significantly higher levels of Enterococci compared to the control group (p-Value <0.05), while the levels of Bifidobacterium spp. and Escherichia coli were lower in the study group (p-Value <0.05). GFR was lower, and the levels of BUN, SCr, and CysC were higher in the study group compared to the control group (all p-Value <0.05). GFR, BUN, SCr and CysC levels in the study group negatively correlated with the levels of Bifidobacterium spp. and Lactobacillus spp. (r<0, P<0.05), and positively correlated with the abundance of Enterococcus spp. and Escherichia coli (r>0, P<0.05) in the intestinal microflora.
Changes in intestinal microbiota are associated with a significant decrease in GFR and a marked increase in serum levels of renal function indicators, and alterations in the balance of intestinal microbiota may lead to further aggravation of the renal function damage in patients with CRF.
确定慢性肾衰竭（CRF）患者肠道微生物群变化与肾功能之间的关联。
这项回顾性病例对照研究纳入了50例CRF患者（研究组），于2021年3月至2022年5月入住深圳市人民医院临床检验科，以及50名健康个体（对照组）。分析肠道微生物群分布与肾小球滤过率（GFR）、血清肌酐（SCr）、血尿素氮（BUN）和血清胱抑素C（CysC）水平之间的关联。
与对照组相比，CRF患者肠道微生物群中的肠球菌水平显著更高（p值<0.05），而研究组中的双歧杆菌属和大肠杆菌水平较低（p值<0.05）。与对照组相比，研究组的GFR较低，BUN、SCr和CysC水平较高（所有p值<0.05）。研究组中的GFR、BUN、SCr和CysC水平与肠道微生物群中双歧杆菌属和乳酸杆菌属的水平呈负相关（r<0，P<0.05），与肠球菌属和大肠杆菌的丰度呈正相关（r>0，P<0.05）。
肠道微生物群的变化与GFR显著降低和肾功能指标血清水平显著升高有关，肠道微生物群平衡的改变可能导致CRF患者肾功能损害进一步加重。
