Institute of Computational Mathematics, AG PDE, TU Braunschweig, Universitätsplatz 2, 38106, Braunschweig, Germany.
Bull Math Biol. 2019 Nov;81(11):4743-4760. doi: 10.1007/s11538-019-00596-y. Epub 2019 Mar 19.
Here, we discuss how the tendency of a liver infection to chronify can be seen as an evolutionary advantage for infected individuals. For this purpose, we present a set of reaction-diffusion equations as a mathematical model of viral liver infections, which allows chronic and acute courses of the liver infection. We introduce a cumulative wealth function, and finally, we show that an immune response favoring the chronification is evolutionary advantageous at the same time.
在这里,我们讨论肝脏感染趋向慢性化如何被视为受感染个体的进化优势。为此,我们提出了一组反应扩散方程作为病毒肝脏感染的数学模型,该模型允许肝脏感染呈现慢性和急性病程。我们引入了一个累积财富函数,最后,我们表明有利于慢性化的免疫反应同时具有进化优势。