Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
School of Paediatrics and Child Health, The University of Western Australia, Perth, Western Australia, Australia.
Int J Eat Disord. 2019 Jun;52(6):643-651. doi: 10.1002/eat.23073. Epub 2019 Mar 20.
The fetal programming model hypothesizes that developmental programming in utero and in early life induces adaptations that predetermine the adult phenotype. This study investigated whether prenatal/perinatal complications are associated with lifetime eating disorders in women.
Participants included 46,373 adult women enrolled in the Norwegian Mother and Child Cohort Study (den norske Mor & barn-undersøkelsen [MoBa]). MoBa mothers and their mothers (MoBa grandmothers) were the focus of the current study. MoBa mothers with lifetime eating disorders were compared to a referent group.
MoBa mothers who weighed more at birth (birth weight, adjusted odds ratio [OR] = 1.14; 95% confidence interval [CI]: 1.10-1.19) or were born large-for-gestational-age (adjusted OR = 1.39; 95% CI: 1.27-1.52) were more likely to develop binge-eating disorder in later life. MoBa mothers who weighed less at birth were more likely to develop anorexia nervosa (birth weight, adjusted OR = 0.88; 95% CI: 0.81-0.95). Bulimia nervosa and purging disorder (PD) were not significantly predicted by the prenatal and perinatal factors examined.
Results of this study, which include the first known investigation of prenatal and perinatal factors in binge-eating disorder and PD, suggest that fetal programming may be relevant to the development of anorexia nervosa and binge-eating disorder. Future genetically informative research is needed to help disentangle whether these associations are a function of genetic influences or a true environmental fetal programming effect.
胎儿编程模型假设宫内和生命早期的发育编程会诱导适应，从而预先决定成人表型。本研究调查了产前/围产期并发症是否与女性终身饮食失调有关。
参与者包括参加挪威母亲和儿童队列研究（den norske Mor & barn-undersøkelsen [MoBa]）的 46373 名成年女性。MoBa 母亲及其母亲（MoBa 祖母）是本研究的重点。MoBa 患有终身饮食失调的母亲与参照组进行了比较。
出生时体重较重（出生体重，调整后的优势比 [OR] = 1.14；95%置信区间 [CI]：1.10-1.19）或出生时为巨大儿（调整后的 OR = 1.39；95% CI：1.27-1.52）的 MoBa 母亲更有可能在以后的生活中患上暴食症。出生体重较轻的 MoBa 母亲更有可能患上厌食症（出生体重，调整后的 OR = 0.88；95% CI：0.81-0.95）。贪食症和清除障碍（PD）不能通过所检查的产前和围产期因素来预测。
本研究结果包括对暴食症和 PD 中产前和围产期因素的首次已知调查，表明胎儿编程可能与厌食症和暴食症的发展有关。未来需要进行具有遗传信息的研究，以帮助阐明这些关联是遗传影响的结果还是真正的环境胎儿编程效应。
