Souza Neto Júnior José de Castro, Estevão Lígia Reis de Moura, Ferraz Adriana Aparecida, Simões Ricardo Santos, Vieira Marcela Gabriela Feitosa, Evêncio-Neto Joaquim
Fellow PhD degree, Postgraduate Program in Animal Bioscience, Department of Morphology and Animal Physiology, Universidade Federal Rural de Pernambuco (UFRPE), Recife-PE, Brazil. Acquisition and interpretation of data, technical procedures, histopathological examinations, statistics analysis, manuscript preparation.
PhD, Department of Morphology and Animal Physiology, UFRPE, Recife-PE, Brazil. Acquisition, analysis and interpretation of data; manuscript writing.
Acta Cir Bras. 2019 Mar 18;34(3):e201900307. doi: 10.1590/s0102-865020190030000007.
To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats.
Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hydroalcoholic extract of X. americana applied on 10%, Lanette base and Control, untreated wounds. The treatment was performed daily and the wounds evaluated microscopically by the quantification of fibroblasts, collagen fibers and blood vessels.
The histomorphometric analysis showed a significant increase in the number of fibroblasts, collagen fibers and blood vessels in the treated group.
The topical action of the cream based on Ximenia americana shows angiogenic effects and improves the replacement of collagen, suggesting its use for the development of herbal remedy in the treatment of cutaneous wound healing.
评估海檀木水醇提取物10%乳膏在大鼠切除伤口模型中的愈合潜力。
60只成年雄性Wistar大鼠在左右胸部区域进行皮肤和皮下组织手术，分为三个实验组：标准组仅用基础载体治疗，治疗组伤口用10%海檀木水醇提取物、Lanette基质治疗，对照组为未治疗的伤口。每天进行治疗，并通过对成纤维细胞、胶原纤维和血管的定量分析对伤口进行显微镜评估。
组织形态计量学分析显示治疗组中成纤维细胞、胶原纤维和血管数量显著增加。
基于海檀木的乳膏的局部作用显示出血管生成作用，并改善了胶原蛋白的替代，表明其可用于开发治疗皮肤伤口愈合的草药疗法。
