未成熟粒细胞百分比升高在急性坏死性胰腺炎早期预测中的作用
Role of increased immature granulocyte percentage in the early prediction of acute necrotizing pancreatitis.
作者信息
Ünal Yılmaz, Barlas Aziz Mutlu
机构信息
Department of General Surgery, Ankara Training and Research Hospital, Ankara-Turkey.
出版信息
Ulus Travma Acil Cerrahi Derg. 2019 Mar;25(2):177-182. doi: 10.14744/tjtes.2019.70679.
BACKGROUND
Acute necrotizing pancreatitis (ANP) is the most severe form of acute pancreatitis (AP), and it has high mortality rates. Therefore, early diagnosis and treatment are of critical importance for the prognosis. The aim of this study was to investigate the effectiveness of immature granulocyte percentage (IG%) in the early prediction of ANP.
METHODS
This retrospective study included 96 adult patients hospitalized with a diagnosis of AP. Demographic data of the patients were recorded. The white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), IG%, C-reactive protein (CRP), and amylase levels were determined. Furthermore, computed abdominal tomography was applied to the patients, and the length of hospital stay was recorded. Patients were divided into two groups as those with acute edematous pancreatitis and ANP, according to the tomography results. The differences between the groups were analyzed statistically.
RESULTS
The WBC count, NLR, CRP, and IG% were significant markers in the prediction of ANP. However, IG% had higher values with regard to the sensitivity, specificity, AUROC, and negative and positive predictive values (100%, 95%, 0.982, 78.9%, and 100%, respectively).
CONCLUSION
An increased IG% is a simple, fast, and effective marker in the early prediction of ANP.
METHODS
This retrospective study was carried out on 96 adult patients who were hospitalized with a diagnosis of acute pancreatitis. Demographic data of the patients were recorded. White blood cell count, neutrophil/lymphocyte ratio, IG%, C-reactive protein and amylase levels were determined. Furthermore computed abdominal tomography was applied to the patients and the length of hospital stay was recorded. The patients were divided into two groups as acute edematous pancreatitis and acute necrotizing pancreatitis according to the tomography results. The differences between the groups were analyzed statistically.
RESULTS
White blood cell count, neutrophil/lymphocyte ratio, C-reactive protein and IG% were significant markers in the prediction of acute necrotizing pancreatitis. However, IG% had higher values of sensitivity, specificity, AUROC, negative and positive predictive values ( 100%, 95%, 0.982, 78.9%, 100%,respectively).
CONCLUSION
Increased IG% is a simple, fast, and effective marker in the early prediction of acute necrotizing pancreatitis.
背景
急性坏死性胰腺炎（ANP）是急性胰腺炎（AP）最严重的形式，死亡率很高。因此，早期诊断和治疗对预后至关重要。本研究的目的是探讨未成熟粒细胞百分比（IG%）在ANP早期预测中的有效性。
方法
这项回顾性研究纳入了96例诊断为AP的成年住院患者。记录患者的人口统计学数据。测定白细胞（WBC）计数、中性粒细胞与淋巴细胞比值（NLR）、IG%、C反应蛋白（CRP）和淀粉酶水平。此外，对患者进行腹部计算机断层扫描，并记录住院时间。根据断层扫描结果，将患者分为急性水肿性胰腺炎组和ANP组。对两组间的差异进行统计学分析。
结果
WBC计数、NLR、CRP和IG%是预测ANP的重要指标。然而，IG%在敏感性、特异性、曲线下面积（AUROC）以及阴性和阳性预测值方面具有更高的值（分别为100%、95%、0.982、78.9%和100%）。
结论
IG%升高是ANP早期预测中一种简单、快速且有效的指标。
方法
本回顾性研究对96例诊断为急性胰腺炎的成年患者进行。记录患者的人口统计学数据。测定白细胞计数、中性粒细胞/淋巴细胞比值、IG%、C反应蛋白和淀粉酶水平。此外，对患者进行腹部计算机断层扫描，并记录住院时间。根据断层扫描结果，将患者分为急性水肿性胰腺炎组和急性坏死性胰腺炎组。对两组间的差异进行统计学分析。
结果
白细胞计数、中性粒细胞/淋巴细胞比值、C反应蛋白和IG%是预测急性坏死性胰腺炎的重要指标。然而，IG%在敏感性、特异性、AUROC、阴性和阳性预测值方面具有更高的值（分别为100%、95%、0.982、78.9%、100%）。
结论
IG%升高是急性坏死性胰腺炎早期预测中一种简单、快速且有效的指标。
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