Burton G W, Cheng S C, Webb A, Ingold K U
Biochim Biophys Acta. 1986 Aug 7;860(1):84-90. doi: 10.1016/0005-2736(86)90501-8.
Young and old human red blood cells contain about the same amount of alpha-tocopherol, a compound which has previously been shown to be the major lipid-soluble, chain-breaking antioxidant present in such cells. Since red blood cells lose up to ca. 20% of lipid material from their membrane as they age, the alpha-tocopherol/membrane-lipid ratio actually rises with age rather than declining as might have been expected on the basis of the free radical theory of aging. The alpha-tocopherol/arachidonic acid moiety ratios increase in the order: young red blood cells less than old red blood cells less than plasma, which argues against the suggested membrane stabilizing effect of alpha-tocopherol/arachidonic acid moiety complexes.
年轻和年老的人类红细胞所含的α-生育酚量大致相同，α-生育酚是一种化合物，此前已被证明是这类细胞中主要的脂溶性链断裂抗氧化剂。由于红细胞随着衰老，其膜上高达约20%的脂质物质会流失，因此α-生育酚与膜脂质的比例实际上会随着年龄增长而升高，而非如基于衰老自由基理论所预期的那样下降。α-生育酚与花生四烯酸部分的比例按以下顺序增加：年轻红细胞＜年老红细胞＜血浆，这与α-生育酚/花生四烯酸部分复合物所暗示的膜稳定作用相悖。
