Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), and Departamento de Química Orgánica , Universidade de Santiago de Compostela , 15782 Santiago de Compostela , Spain.
J Am Chem Soc. 2019 Apr 3;141(13):5125-5129. doi: 10.1021/jacs.9b00837. Epub 2019 Mar 22.
Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the "in cellulo" generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.
定制的钌（IV）配合物可以在生理相关条件下，甚至在活的哺乳动物细胞内，催化烯丙醇异构化为饱和羰基衍生物。该反应涉及钌-氢化物中间体，是生物正交和生物相容的，可以用于“在细胞内”生成荧光和生物活性探针。总的来说，我们的研究揭示了一种用于细胞干预的新型基于金属的工具，并进一步证明了有机金属机制与细胞复杂环境的兼容性。
