a Department of Ophthalmology , Kangwon National University School of Medicine, Kangwon National University Hospital , Chuncheon , Korea.
b Department of Ophthalmology , Seoul National University College of Medicine, Seoul National University Bundang Hospital , Seongnam , Korea.
Curr Eye Res. 2019 Jul;44(7):806-812. doi: 10.1080/02713683.2019.1591461. Epub 2019 Mar 25.
: To evaluate the efficacy of polytetrafluoroethylene/polylactide-co-glycolide (PTFE/PLGA) laminate containing sustained-release thalidomide for delayed adjustable strabismus surgery. : This is a prospective, masked-observer, controlled study using 50 eyes of 25 rabbits. After superior rectus muscle (SRM) recession, a PTFE/PLGA laminate containing thalidomide (group PT, 20 eyes), PTFE/PLGA laminate alone (group P, 20 eyes), or no barrier (group C, 10 eyes) were applied around the SRM. Delayed adjustment was performed at postoperative 3 or 5 weeks. Adjustability, adjustment lengths, adjustment forces, and degrees of adhesion were evaluated. : Both groups PT and P showed significantly better adjustability compared to group C at both 3 weeks (100%, 80%, and 0%, respectively) and 5 weeks (100%, 90%, and 0%, respectively). Between groups PT and P, adjustability, adjustment lengths, and forces were not significantly different at 3 and 5 weeks. Group PT showed a significantly lower grade of adhesion between SRM and sclera (SRM/S) compared to group C at both 3 weeks ( = 0.007) and 5 weeks ( = 0.001, respectively). Group P showed no significant difference in adhesion between SRM/S compared to group C at 3 weeks (= 0.302) but had a lower grade of adhesion after 5 weeks ( = 0.007). There was no significant difference between groups PT and P at 3 weeks (= 0.143) and 5 weeks (= 0.716). : PTFE/PLGA laminate containing sustained-release thalidomide was effective in reducing adhesion and allowed delayed adjustment in all eyes. However, PTFE/PLGA laminate alone was also equally effective in reducing adhesion compared to controls.
评价含持续释放沙利度胺的聚四氟乙烯/聚乳酸-羟基乙酸共聚物（PTFE/PLGA）层压物用于延迟可调节斜视手术的疗效。
这是一项前瞻性、盲法观察者、对照研究，共纳入 25 只兔子的 50 只眼。在进行上直肌（SRM）后退术后，将含沙利度胺的 PTFE/PLGA 层压物（PT 组，20 只眼）、单纯 PTFE/PLGA 层压物（P 组，20 只眼）或不使用任何屏障（C 组，10 只眼）应用于 SRM 周围。在术后 3 或 5 周时进行延迟调整。评估调节性、调节长度、调节力和粘连程度。
PT 组和 P 组在术后 3 周（分别为 100%、80%和 0%）和 5 周（分别为 100%、90%和 0%）时的调节性明显优于 C 组。在 3 周和 5 周时，PT 组和 P 组之间的调节性、调节长度和力无显著差异。PT 组在术后 3 周（=0.007）和 5 周（=0.001）时，SRM 与巩膜（SRM/S）之间的粘连程度明显低于 C 组（=0.007）。P 组在术后 3 周时与 C 组相比，SRM/S 的粘连程度无显著差异（=0.302），但 5 周后粘连程度较低（=0.007）。PT 组和 P 组在 3 周（=0.143）和 5 周（=0.716）时无显著差异。
含持续释放沙利度胺的 PTFE/PLGA 层压物可有效减少粘连，并使所有眼睛均能进行延迟调整。然而，与对照组相比，单纯的 PTFE/PLGA 层压物在减少粘连方面也同样有效。
