Orwin A, Wright C E, Harding G F, Rowan D C, Rolfe E B
Br Med J (Clin Res Ed). 1986 Jul 5;293(6538):9-10. doi: 10.1136/bmj.293.6538.9.
Primary presenile dementia slows the major positive component of the visual evoked potential to flash stimulation but does not affect the visual evoked potential to patterned stimulation. The progressive effect of Alzheimer's disease was followed in a 58 year old woman over three and a half years from the development of the earliest symptoms to complete mental incapacity. The pattern reversal visual evoked potential remained normal, but the flash visual evoked potential gradually slowed from 129 ms in 1981 to 153 ms in 1984. The severity of the abnormality of the flash visual evoked potential thus reflected the severity of the dementia. Electroencephalography, computed tomography, and psychometric tests indicated generalised cortical disease, but the results were not specific to dementia. The combination of a slowed flash and normal pattern visual evoked potential seems to be specific to Alzheimer's disease and supports the use of flash and pattern visual evoked potentials in routine diagnostic testing for this condition.
早老性原发性痴呆会减慢闪光刺激诱发的视觉诱发电位的主要正向成分，但不影响图形刺激诱发的视觉诱发电位。对一名58岁女性从出现最早症状到完全丧失心智能力的三年半时间里，追踪了阿尔茨海默病的进展情况。图形翻转视觉诱发电位保持正常，但闪光视觉诱发电位从1981年的129毫秒逐渐减慢至1984年的153毫秒。因此，闪光视觉诱发电位异常的严重程度反映了痴呆的严重程度。脑电图、计算机断层扫描和心理测试表明存在广泛性皮质疾病，但结果并非痴呆所特有。闪光视觉诱发电位减慢而图形视觉诱发电位正常的组合似乎是阿尔茨海默病所特有的，支持在这种疾病的常规诊断测试中使用闪光和图形视觉诱发电位。
