Wright C E, Harding G F, Orwin A
Electroencephalogr Clin Neurophysiol. 1984 May;57(5):405-15. doi: 10.1016/0013-4694(84)90069-5.
Flash, pattern reversal and pattern onset-offset VEPs were recorded in 17 patients with a clinical diagnosis of presenile dementia. The results were compared with those from two control groups--17 normal volunteers of equivalent ages and 17 patients from the same psychiatric hospital with affective disorders but no clinical evidence of dementia. The flash P2 component was found to be significantly delayed in the group of patients with dementia, but the latency of the P1 component and pattern VEP components were all within normal limits. This unusual finding presents a useful index for the diagnosis of presenile dementia.
对17例临床诊断为早老性痴呆的患者记录了闪光、图形翻转和图形起止视觉诱发电位（VEP）。将结果与两个对照组进行比较——17名年龄相当的正常志愿者以及17名来自同一精神病院、患有情感障碍但无痴呆临床证据的患者。发现痴呆患者组的闪光P2成分明显延迟，但P1成分和图形VEP成分的潜伏期均在正常范围内。这一不寻常的发现为早老性痴呆的诊断提供了一个有用的指标。
