Moazen Mehran, Calder Peter, Koroma Paul, Wright Jonathan, Taylor Stephen, Blunn Gordon
1 Department of Mechanical Engineering, University College London, London, UK.
2 Institute of Orthopaedics and Musculoskeletal Science, Division of Surgery & Interventional Science, University College London, Royal National Orthopaedic Hospital, Stanmore, UK.
Proc Inst Mech Eng H. 2019 May;233(5):595-599. doi: 10.1177/0954411919837304. Epub 2019 Mar 20.
Several studies have investigated the effect of low-magnitude-high-frequency vibration on the outcome of fracture healing in animal models. The aim of this study was to quantify and compare the micromovement at the fracture gap in a tibial fracture fixed with an external fixator in both a surrogate model of a tibial fracture and a cadaver human leg under static loading, both subjected to vibration. The constructs were loaded under static axial loads of 50, 100, 150 and 200 N and then subjected to vibration at each load using a commercial vibration platform, using a DVRT sensor to quantify static and dynamic fracture movement. The overall stiffness of the cadaver leg was significantly higher than the surrogate model under static loading. This resulted in a significantly higher fracture movement in the surrogate model. Under vibration, the fracture movements induced at the fracture gap in the surrogate model and the cadaver leg were 0.024 ± 0.009 mm and 0.016 ± 0.002 mm, respectively, at 200 N loading. Soft tissues can alter the overall stiffness and fracture movement recorded in biomechanical studies investigating the effect of various devices or therapies. While the relative comparison between the devices or therapies may remain valid, absolute magnitude of recordings measured externally must be interpreted with caution.
多项研究调查了低强度高频振动对动物模型骨折愈合结果的影响。本研究的目的是在静态加载下，对使用外固定器固定的胫骨骨折的骨折间隙微移动进行量化和比较，该研究在胫骨骨折替代模型和尸体人腿上进行，两者均承受振动。构建体在50、100、150和200 N的静态轴向载荷下加载，然后使用商用振动平台在每个载荷下进行振动，使用DVRT传感器量化静态和动态骨折移动。在静态加载下，尸体腿的整体刚度显著高于替代模型。这导致替代模型中的骨折移动显著更高。在振动下，在200 N载荷下，替代模型和尸体腿骨折间隙处诱导的骨折移动分别为0.024±0.009 mm和0.016±0.002 mm。软组织可改变生物力学研究中记录的整体刚度和骨折移动，这些研究旨在调查各种装置或治疗方法的效果。虽然装置或治疗方法之间的相对比较可能仍然有效，但从外部测量的记录的绝对大小必须谨慎解释。
