Wu Xian-Rong, He Xiao-Hong, Xie Yong-Fang
School of Life Health Information Science and Engineering, Chongqing Post and Communications University, Chongqing 400065, China.
World J Gastrointest Oncol. 2025 Jan 15;17(1):98872. doi: 10.4251/wjgo.v17.i1.98872.
This editorial, inspired by a recent study published in the , covers the research findings on microbiota changes in various diseases. In recurrent colorectal polyps, the abundances of , , and increase, while those of and decrease. This dysbiosis may promote the formation and recurrence of polyps. Similar microbial changes have also been observed in colorectal cancer, inflammatory bowel disease, autism spectrum disorder, and metabolic syndrome, indicating the role of increased pathogens and decreased probiotics in these conditions. Regulating the gut microbiota, particularly by increasing probiotic levels, may help prevent polyp recurrence and promote gut health. This microbial intervention strategy holds promise as an adjunctive treatment for patients with colorectal polyps.
这篇受近期发表在《》上的一项研究启发而撰写的社论,涵盖了关于各种疾病中微生物群变化的研究结果。在复发性结肠直肠息肉中,[具体微生物名称1]、[具体微生物名称2]和[具体微生物名称3]的丰度增加,而[具体微生物名称4]和[具体微生物名称5]的丰度降低。这种生态失调可能促进息肉的形成和复发。在结直肠癌、炎症性肠病、自闭症谱系障碍和代谢综合征中也观察到了类似的微生物变化,表明在这些病症中病原体增加和益生菌减少所起的作用。调节肠道微生物群,特别是通过提高益生菌水平,可能有助于预防息肉复发并促进肠道健康。这种微生物干预策略有望成为结肠直肠息肉患者的辅助治疗方法。