缺血性心脏病和糖尿病患者心外膜脂肪组织中清道夫受体的过度表达和巨噬细胞的浸润。
Overexpression of scavenger receptor and infiltration of macrophage in epicardial adipose tissue of patients with ischemic heart disease and diabetes.
机构信息
Department of Endocrinology and Nutrition, Virgen de la Victoria Hospital (IBIMA), Malaga University, Campus de Teatinos s/n, 29010, Malaga, Spain.
Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Malaga, Spain.
出版信息
J Transl Med. 2019 Mar 20;17(1):95. doi: 10.1186/s12967-019-1842-2.
BACKGROUND
Oxidized low-density lipoproteins and scavenger receptors (SRs) play an important role in the formation and development of atherosclerotic plaques. However, little is known about their presence in epicardial adipose tissue (EAT). The objective of the study was to evaluate the mRNA expression of different SRs in EAT of patients with ischemic heart disease (IHD), stratifying by diabetes status and its association with clinical and biochemical variables.
METHODS
We analyzed the mRNA expression of SRs (LOX-1, MSR1, CXCL16, CD36 and CL-P1) and macrophage markers (CD68, CD11c and CD206) in EAT from 45 patients with IHD (23 with type 2 diabetes mellitus (T2DM) and 22 without T2DM) and 23 controls without IHD or T2DM.
RESULTS
LOX-1, CL-P1, CD68 and CD11c mRNA expression were significantly higher in diabetic patients with IHD when compared with those without T2DM and control patients. MSR1, CXCL16, CD36 and CD206 showed no significant differences. In IHD patients, LOX-1 (OR 2.9; 95% CI 1.6-6.7; P = 0.019) and CD68 mRNA expression (OR 1.7; 95% CI 0.98-4.5; P = 0.049) were identified as independent risk factors associated with T2DM. Glucose and glycated hemoglobin were also shown to be risk factors.
CONCLUSIONS
SRs mRNA expression is found in EAT. LOX-1 and CD68 and were higher in IHD patients with T2DM and were identified as a cardiovascular risk factor of T2DM. This study suggests the importance of EAT in coronary atherosclerosis among patients with T2DM.
背景
氧化型低密度脂蛋白和清道夫受体（SRs）在动脉粥样硬化斑块的形成和发展中起重要作用。然而，关于它们在心脏外膜脂肪组织（EAT）中的存在知之甚少。本研究旨在评估不同 SRs 在缺血性心脏病（IHD）患者 EAT 中的 mRNA 表达，按糖尿病状态分层，并分析其与临床和生化变量的关系。
方法
我们分析了 45 例 IHD 患者（23 例合并 2 型糖尿病（T2DM），22 例无 T2DM）和 23 例无 IHD 或 T2DM 的对照者的 EAT 中 SRs（LOX-1、MSR1、CXCL16、CD36 和 CL-P1）和巨噬细胞标志物（CD68、CD11c 和 CD206）的 mRNA 表达。
结果
与无 T2DM 的患者和对照组相比，合并 T2DM 的 IHD 患者的 LOX-1、CL-P1、CD68 和 CD11c mRNA 表达明显升高，而 MSR1、CXCL16、CD36 和 CD206 无明显差异。在 IHD 患者中，LOX-1（OR 2.9；95%CI 1.6-6.7；P=0.019）和 CD68 mRNA 表达（OR 1.7；95%CI 0.98-4.5；P=0.049）被确定为与 T2DM 相关的独立危险因素。血糖和糖化血红蛋白也被证明是危险因素。
结论
SRs 的 mRNA 表达存在于 EAT 中。在合并 T2DM 的 IHD 患者中，LOX-1 和 CD68 的表达更高，并被确定为 T2DM 的心血管危险因素。本研究提示了 EAT 在 T2DM 患者冠状动脉粥样硬化中的重要性。
Zotero 插件