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路易斯安那州新奥尔良市孕妇梅毒当代管理面临的挑战

Challenges in the Contemporary Management of Syphilis among Pregnant Women in New Orleans, LA.

作者信息

Stafford Irene A, Berra Alexandra, Minard Charles G, Fontenot Virginia, Kopkin Rachel H, Rodrigue Eliza, Roitsch Charles M, Rac Martha W, Hill James B

机构信息

Baylor College of Medicine/Texas Children's Hospital, Department of Obstetrics and Gynecology, Houston, TX, USA.

Louisiana State University Health Sciences Center, Department of Obstetrics and Gynecology, New Orleans, LA, USA.

出版信息

Infect Dis Obstet Gynecol. 2019 Feb 13;2019:2613962. doi: 10.1155/2019/2613962. eCollection 2019.

Abstract

OBJECTIVE

The aim of this retrospective review is to evaluate trends in the management of maternal and congenital syphilis (CS) in a tertiary care center in New Orleans, LA.

STUDY DESIGN

All cases of maternal and neonatal syphilis over a five year period at Touro Infirmary, New Orleans, LA, were identified using ICD-9/10 codes. Charts were reviewed for demographic and obstetrical variables, stage of syphilis at diagnosis, lab values, and treatment regimen. Newborn treatment and other outcomes were recorded.

RESULTS

During the study period 106 infected mother-baby pairs were identified. Of these, 73 charts are available for review. 41% (n = 30) of women received inadequate therapy according to their stage of disease. 9% of newborns (n = 6) were found to be symptomatic for CS; however, only 83.3% of these were admitted to the neonatal intensive care unit. Only 20% (n = 6) of infants were adequately treated with an extended penicillin regimen if the mother was not adequately treated. Furthermore, only 63.0% of newborns had a nontreponemal titer performed.

CONCLUSION

With rising rates of CS, strict adherence to the 2015 CDC guidelines for treatment of syphilis must be maintained.

摘要

目的

本回顾性研究旨在评估路易斯安那州新奥尔良市一家三级医疗中心孕产妇和先天性梅毒(CS)的管理趋势。

研究设计

使用ICD - 9/10编码确定路易斯安那州新奥尔良市图罗医院五年期间所有孕产妇和新生儿梅毒病例。查阅病历以获取人口统计学和产科变量、诊断时梅毒分期、实验室检查值及治疗方案。记录新生儿治疗情况及其他结局。

结果

在研究期间,共确定了106对感染母婴。其中,73份病历可供查阅。41%(n = 30)的女性根据其疾病分期接受了不充分的治疗。9%的新生儿(n = 6)出现先天性梅毒症状;然而,其中只有83.3%被收入新生儿重症监护病房。如果母亲未得到充分治疗,只有20%(n = 6)的婴儿接受了延长青霉素疗程的充分治疗。此外,只有63.0%的新生儿进行了非梅毒螺旋体滴度检测。

结论

随着先天性梅毒发病率的上升,必须严格遵循2015年美国疾病控制与预防中心梅毒治疗指南。

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本文引用的文献

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Infectious and congenital syphilis in Canada, 2010-2015.2010 - 2015年加拿大的感染性和先天性梅毒
Can Commun Dis Rep. 2018 Feb 1;44(2):43-48. doi: 10.14745/ccdr.v44i02a02.
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Syphilis during pregnancy: a preventable threat to maternal-fetal health.妊娠期梅毒:对母婴健康的可预防威胁。
Am J Obstet Gynecol. 2017 Apr;216(4):352-363. doi: 10.1016/j.ajog.2016.11.1052. Epub 2016 Dec 9.
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Progression of ultrasound findings of fetal syphilis after maternal treatment.母体治疗后胎儿梅毒超声检查结果的进展
Am J Obstet Gynecol. 2014 Oct;211(4):426.e1-6. doi: 10.1016/j.ajog.2014.05.049. Epub 2014 Jun 4.
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A systematic review of pediatric sensorineural hearing loss in congenital syphilis.先天性梅毒患儿感音神经性听力损失的系统评价
Int J Pediatr Otorhinolaryngol. 2009 Jun;73(6):787-92. doi: 10.1016/j.ijporl.2009.02.021. Epub 2009 Mar 24.

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