Stafford Irene A, Berra Alexandra, Minard Charles G, Fontenot Virginia, Kopkin Rachel H, Rodrigue Eliza, Roitsch Charles M, Rac Martha W, Hill James B
Baylor College of Medicine/Texas Children's Hospital, Department of Obstetrics and Gynecology, Houston, TX, USA.
Louisiana State University Health Sciences Center, Department of Obstetrics and Gynecology, New Orleans, LA, USA.
Infect Dis Obstet Gynecol. 2019 Feb 13;2019:2613962. doi: 10.1155/2019/2613962. eCollection 2019.
The aim of this retrospective review is to evaluate trends in the management of maternal and congenital syphilis (CS) in a tertiary care center in New Orleans, LA.
All cases of maternal and neonatal syphilis over a five year period at Touro Infirmary, New Orleans, LA, were identified using ICD-9/10 codes. Charts were reviewed for demographic and obstetrical variables, stage of syphilis at diagnosis, lab values, and treatment regimen. Newborn treatment and other outcomes were recorded.
During the study period 106 infected mother-baby pairs were identified. Of these, 73 charts are available for review. 41% (n = 30) of women received inadequate therapy according to their stage of disease. 9% of newborns (n = 6) were found to be symptomatic for CS; however, only 83.3% of these were admitted to the neonatal intensive care unit. Only 20% (n = 6) of infants were adequately treated with an extended penicillin regimen if the mother was not adequately treated. Furthermore, only 63.0% of newborns had a nontreponemal titer performed.
With rising rates of CS, strict adherence to the 2015 CDC guidelines for treatment of syphilis must be maintained.
本回顾性研究旨在评估路易斯安那州新奥尔良市一家三级医疗中心孕产妇和先天性梅毒(CS)的管理趋势。
使用ICD - 9/10编码确定路易斯安那州新奥尔良市图罗医院五年期间所有孕产妇和新生儿梅毒病例。查阅病历以获取人口统计学和产科变量、诊断时梅毒分期、实验室检查值及治疗方案。记录新生儿治疗情况及其他结局。
在研究期间,共确定了106对感染母婴。其中,73份病历可供查阅。41%(n = 30)的女性根据其疾病分期接受了不充分的治疗。9%的新生儿(n = 6)出现先天性梅毒症状;然而,其中只有83.3%被收入新生儿重症监护病房。如果母亲未得到充分治疗,只有20%(n = 6)的婴儿接受了延长青霉素疗程的充分治疗。此外,只有63.0%的新生儿进行了非梅毒螺旋体滴度检测。
随着先天性梅毒发病率的上升,必须严格遵循2015年美国疾病控制与预防中心梅毒治疗指南。