Chiang Chun-Pin, Wu Yu-Hsueh, Yu-Fong Chang Julia, Wang Yi-Ping, Chen Hsin-Ming, Sun Andy
Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan.
J Dent Sci. 2018 Sep;13(3):256-262. doi: 10.1016/j.jds.2018.05.001. Epub 2018 Jun 7.
BACKGROUND/PURPOSE: Our previous study found that 13 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have thyroglobulin antibody (TGA) positivity and/or thyroid microsomal antibody (TMA) positivity (TGA/TMA positivity) but without gastric parietal cell antibody positivity. This study mainly assessed whether the serum TGA/TMA positivity was significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in TGA/TMA-positive RAS/BD patients.
The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between 13 TGA/TMA-positive RAS/BD patients and 41 gastric and thyroid antibodies-negative RAS/BD patients (Abs־RAS/BD patients) or 126 healthy control subjects.
We found no significant differences in the mean blood Hb, iron, vitamin B12, folic acid, and homocysteine leve1s as well as no significant differences in the frequencies of blood Hb and folic acid deficiencies and of hyperhomocysteinemia between 13 TGA/TMA-positive RAS/BD patients and 41 Abs־RAS/BD patients. The 41 Abs־RAS/BD patients even had a significantly greater frequency of serum iron deficiency than the 13 TGA/TMA-positive RAS/BD patients. Moreover, although a significant greater frequency of anemia was demonstrated in 13 TGA/TMA-positive RAS/BD patients than in 126 healthy control subjects, there were no significant differences in the mean serum iron, vitamin B12, folic acid, and homocysteine levels as well as no significant differences in the frequencies of serum iron and folic acid deficiencies and of hyperhomocysteinemia between 13 TGA/TMA-positive RAS/BD patients and 126 healthy control subjects.
The serum TGA/TMA-positivity is not significantly associated with anemia, hematinic deficiencies, and hyperhomocysteinemia in TGA/TMA-positive RAS/BD patients.
背景/目的：我们之前的研究发现，63例复发性阿弗他口炎（RAS）/白塞病（BD）患者中有13例存在甲状腺球蛋白抗体（TGA）阳性和/或甲状腺微粒体抗体（TMA）阳性（TGA/TMA阳性），但无胃壁细胞抗体阳性。本研究主要评估血清TGA/TMA阳性与TGA/TMA阳性的RAS/BD患者的贫血、造血物质缺乏及高同型半胱氨酸血症是否显著相关。
测量并比较13例TGA/TMA阳性的RAS/BD患者、41例胃和甲状腺抗体阴性的RAS/BD患者（抗体阴性的RAS/BD患者）以及126例健康对照者的平均血红蛋白（Hb）、铁、维生素B12、叶酸和同型半胱氨酸水平。
我们发现，13例TGA/TMA阳性的RAS/BD患者与41例抗体阴性的RAS/BD患者之间，平均血液Hb、铁、维生素B12、叶酸和同型半胱氨酸水平无显著差异，血液Hb和叶酸缺乏以及高同型半胱氨酸血症的发生率也无显著差异。41例抗体阴性的RAS/BD患者血清铁缺乏的发生率甚至显著高于13例TGA/TMA阳性的RAS/BD患者。此外，虽然13例TGA/TMA阳性的RAS/BD患者的贫血发生率显著高于126例健康对照者，但13例TGA/TMA阳性的RAS/BD患者与126例健康对照者之间，血清铁、维生素B12、叶酸和同型半胱氨酸的平均水平无显著差异，血清铁和叶酸缺乏以及高同型半胱氨酸血症的发生率也无显著差异。
血清TGA/TMA阳性与TGA/TMA阳性的RAS/BD患者的贫血、造血物质缺乏及高同型半胱氨酸血症无显著相关性。
