无血清甲状腺自身抗体的血清胃壁细胞抗体阳性灼口综合征患者的贫血、造血物质缺乏及高同型半胱氨酸血症
Anemia, hematinic deficiencies, and hyperhomocysteinemia in serum gastric parietal cell antibody-positive burning mouth syndrome patients without serum thyroid autoantibodies.
作者信息
Jin Ying-Tai, Wu Yu-Hsueh, Wu Yang-Che, Yu-Fong Chang Julia, Chiang Chun-Pin, Sun Andy
机构信息
Department of Pathology, Taiwan Adventist Hospital, Taipei, Taiwan.
Department of Pathology, National Cheng Kung University Hospital, Tainan, Taiwan.
出版信息
J Dent Sci. 2021 Oct;16(4):1110-1116. doi: 10.1016/j.jds.2021.05.017. Epub 2021 Jun 19.
BACKGROUND/PURPOSE: Our previous study found that 70 of 884 burning mouth syndrome (BMS) patients have serum gastric parietal cell antibody (GPCA) positivity but without thyroglobulin antibody (TGA) and thyroid microsomal antibody (TMA) (so-called GPCATGA-TMA-BMS patients). This study assessed whether these 70 GPCATGA-TMA-BMS patients had significantly higher frequencies of macrocytosis, anemia, hematinic deficiencies, and hyperhomocysteinemia than 553 GPCA-negative, TGA-negative, and TMA-negative BMS (GPCA-TGA-TMA-BMS) patients or 442 healthy control subjects.
MATERIALS AND METHODS
Complete blood count, serum iron, vitamin B12, folic acid, homocysteine, GPCA, TGA, and TMA levels in 70 GPCATGA-TMA-BMS patients, 553 GPCA-TGA-TMA-BMS patients, and 442 healthy control subjects were measured and compared.
RESULTS
We found that 15.7%, 28.6%, 20.0%, 11.4%, 2.9%, and 25.7% of 70 GPCATGA-TMA-BMS patients and 3.8%, 17.7%, 15.9%, 3.8%, 2.7%, and 20.1% of 553 GPCA-TGA-TMA-BMS patients had macrocytosis, blood hemoglobin, iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia, respectively. Moreover, both 70 GPCATGA-TMA-BMS patients and 553 GPCA-TGA-TMA-BMS patients had significantly greater frequencies of macrocytosis, blood hemoglobin, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than 442 healthy control subjects (all -values < 0.05). In addition, 70 GPCATGA-TMA-BMS patients also had greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and hyperhomocysteinemia than 553 GPCA-TGA-TMA-BMS patients (all -values < 0.05).
CONCLUSION
The GPCA TGA-TMA-BMS patients have significantly greater frequencies of macrocytosis, anemia, serum iron, vitamin B12, and folic acid deficiencies, and hyperhomocysteinemia than healthy control subjects and significantly greater frequencies of macrocytosis, anemia, serum vitamin B12 deficiency, and hyperhomocysteinemia than GPCA-TGA-TMA-BMS patients.
背景/目的：我们之前的研究发现，884例灼口综合征（BMS）患者中有70例血清胃壁细胞抗体（GPCA）呈阳性，但无甲状腺球蛋白抗体（TGA）和甲状腺微粒体抗体（TMA）（即所谓的GPCATGA-TMA-BMS患者）。本研究评估了这70例GPCATGA-TMA-BMS患者与553例GPCA阴性、TGA阴性和TMA阴性的BMS（GPCA-TGA-TMA-BMS）患者或442例健康对照者相比，大细胞性贫血、贫血、造血物质缺乏和高同型半胱氨酸血症的发生率是否显著更高。
材料与方法
检测并比较了70例GPCATGA-TMA-BMS患者、553例GPCA-TGA-TMA-BMS患者和442例健康对照者的全血细胞计数、血清铁、维生素B12、叶酸、同型半胱氨酸、GPCA、TGA和TMA水平。
结果
我们发现，70例GPCATGA-TMA-BMS患者中分别有15.7%、28.6%、20.0%、11.4%、2.9%和25.7%，553例GPCA-TGA-TMA-BMS患者中分别有3.8%、17.7%、15.9%、3.8%、2.7%和20.1%出现大细胞性贫血、血红蛋白、铁、维生素B12和叶酸缺乏以及高同型半胱氨酸血症。此外，70例GPCATGA-TMA-BMS患者和553例GPCA-TGA-TMA-BMS患者出现大细胞性贫血、血红蛋白、血清铁、维生素B12和叶酸缺乏以及高同型半胱氨酸血症的频率均显著高于442例健康对照者（所有P值<0.05）。此外，70例GPCATGA-TMA-BMS患者出现大细胞性贫血、贫血、血清维生素B12缺乏和高同型半胱氨酸血症的频率也高于553例GPCA-TGA-TMA-BMS患者（所有P值<0.05）。
结论
GPCATGA-TMA-BMS患者出现大细胞性贫血、贫血、血清铁、维生素B12和叶酸缺乏以及高同型半胱氨酸血症的频率显著高于健康对照者，且出现大细胞性贫血、贫血、血清维生素B12缺乏和高同型半胱氨酸血症的频率显著高于GPCA-TGA-TMA-BMS患者。
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