去氨加压素对自主神经功能衰竭患者夜间多尿、夜间体重减轻及晨起体位性低血压的影响。
The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning postural hypotension in patients with autonomic failure.
作者信息
Mathias C J, Fosbraey P, da Costa D F, Thornley A, Bannister R
出版信息
Br Med J (Clin Res Ed). 1986 Aug 9;293(6543):353-4. doi: 10.1136/bmj.293.6543.353.
Abstract
Day and night urine volume, morning and evening body weight, and supine and sitting blood pressure were measured in five patients with chronic autonomic failure who were not receiving treatment with drugs. All had nocturnal polyuria, overnight weight loss, and a pronounced postural fall in blood pressure, with lowest levels in the morning. Desmopressin (2-4 micrograms given intramuscularly at 8 pm) reduced nocturnal polyuria, diminished overnight weight loss, raised supine blood pressure, and reduced the postural fall, especially in the morning, when patients were often at their worst. Desmopressin may be a useful alternative to, or may supplement, other forms of treatment in some patients with autonomic failure.
摘要
对5名未接受药物治疗的慢性自主神经功能衰竭患者测量了昼夜尿量、早晚体重以及仰卧位和坐位血压。所有患者均有夜间多尿、夜间体重减轻以及明显的体位性血压下降，早晨血压水平最低。去氨加压素（晚上8点肌肉注射2 - 4微克）减少了夜间多尿，减轻了夜间体重减轻，提高了仰卧位血压，并减少了体位性血压下降，尤其是在早晨患者状况通常最差的时候。在一些自主神经功能衰竭患者中，去氨加压素可能是其他治疗方式的有用替代方法或补充方法。
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