Institute of Medical Genetics and Applied Genomics, University of Tübingen, Calwerstraße 7, 72076 Tübingen, Germany.
Department of Human Genetics, Ruhr-University Bochum, Universitätsstraße 150, 44801 Bochum, Germany.
Biomed Res Int. 2019 Feb 14;2019:4741252. doi: 10.1155/2019/4741252. eCollection 2019.
Proteolytic machineries execute vital cellular functions and their disturbances are implicated in diverse medical conditions, including neurodegenerative diseases. Interestingly, calpains, a class of Ca-dependent regulatory proteases, can modulate the degradational system of autophagy by cleaving proteins involved in this pathway. Moreover, both machineries are common players in many molecular pathomechanisms and have been targeted individually or together, as a therapeutic strategy in experimental setups. In this review, we briefly introduce calpains and autophagy, with their roles in health and disease, and focus on their direct pathologically relevant interplay in neurodegeneration and beyond. The modulation of calpain activity may comprise a promising treatment approach to attenuate the deregulation of these two essential mechanisms.
蛋白水解机器执行重要的细胞功能，其功能障碍与多种医学病症有关，包括神经退行性疾病。有趣的是，钙蛋白酶是一类依赖 Ca 的调节蛋白酶，可以通过切割参与该途径的蛋白质来调节自噬的降解系统。此外，这两种机器在许多分子病理机制中都是常见的参与者，并作为一种治疗策略在实验环境中分别或联合进行靶向治疗。在这篇综述中，我们简要介绍了钙蛋白酶和自噬，以及它们在健康和疾病中的作用，并重点关注了它们在神经退行性变及其他疾病中的直接病理相关相互作用。钙蛋白酶活性的调节可能是一种有前途的治疗方法，可以减轻这两种重要机制的失调。
