Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Clinical Research Development Center (CRDU), Qom University of Medical Sciences, Qom, Iran.
J Mol Neurosci. 2019 May;68(1):153-161. doi: 10.1007/s12031-019-01294-z. Epub 2019 Mar 21.
Multiple sclerosis (MS) as a chronic autoimmune disease of the central nervous system (CNS) has been associated with dysregulation of several genes including miRNAs. In the present study, we assessed transcript levels of seven miRNAs (miR-96-5p, miR-211-5p, miR-15a, miR-34a-5p, miR-204-5p, miR-501-5p, and miR-524-5p) in the peripheral blood of MS patients compared with healthy subjects in association with response to fingolimod treatment. Expression levels of miR-211-5p and miR-34a-5p were significantly decreased in MS patients compared with healthy subjects (P values of 0.002 and 0.47). While subgroup analysis showed downregulation of miR-211-5p in both fingolimod responders and non-responders, miR-34a-5p expression was only decreased in responders. Moreover, miR-204-5p was downregulated in non-responder male patients compared with male controls. The current study underscores the role of miRNAs in determination of response to fingolimod in MS patients.
多发性硬化症（MS）是一种中枢神经系统（CNS）的慢性自身免疫性疾病，与包括 microRNA（miRNA）在内的多个基因的失调有关。在本研究中，我们评估了 7 种 miRNA（miR-96-5p、miR-211-5p、miR-15a、miR-34a-5p、miR-204-5p、miR-501-5p 和 miR-524-5p）在外周血中的转录水平，比较了 MS 患者与健康对照者在与 fingolimod 治疗反应相关的情况下。与健康对照组相比，MS 患者的 miR-211-5p 和 miR-34a-5p 的表达水平显著降低（P 值分别为 0.002 和 0.47）。而亚组分析显示，在 fingolimod 应答者和非应答者中，miR-211-5p 均下调，而 miR-34a-5p 的表达仅在应答者中降低。此外，与男性对照组相比，非应答男性患者的 miR-204-5p 下调。本研究强调了 miRNA 在确定 MS 患者对 fingolimod 反应中的作用。
