State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Beijing Key Laboratory of Active Substances Discovery and Drugability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100050, China.
Chem Commun (Camb). 2019 Apr 25;55(35):5064-5067. doi: 10.1039/c9cc00953a.
The extracellular SspA protease of the human pathogen S. aureus is essential for evading the host immune defence system. Two novel FRET probes for selective real-time ratiometric imaging of SspA activity in live S. aureus cells are reported.
金黄色葡萄球菌（S. aureus）是人病原体的细胞外 SspA 蛋白酶，对于逃避宿主免疫系统至关重要。本文报道了两种新型的 FRET 探针，可用于实时选择性比率成像活金黄色葡萄球菌细胞中的 SspA 活性。
