Howard Kerry A, Hunter Amy Silvestri
Department of Psychology, Seton Hall University.
Behav Neurosci. 2019 Oct;133(5):461-466. doi: 10.1037/bne0000312. Epub 2019 Mar 21.
The present study investigated immediate and long-lasting cognitive effects of chronic sleep restriction (CSR) in adolescent rats. After 10 days of CSR produced by gentle handling, both hippocampal-dependent and non-hippocampal-dependent long-term memory abilities were tested using the object location task and the object recognition task, respectively. Testing occurred in adolescence and after a 4-week delay during which rats slept freely and matured to adulthood. Rats exposed to CSR showed impaired memory on the object location task during adolescence that persisted into adulthood. However, there was no effect of CSR on memory for the object recognition task at either time point. These results demonstrate that CSR during adolescence produces an impairment in hippocampal-dependent memory but does not affect non-hippocampal-dependent memory. In addition, this impairment persists even after 4 weeks of undisturbed sleep. This study is the first rodent model to use a longitudinal approach to investigate adolescent CSR and provides practical implications for the health of adolescents. (PsycINFO Database Record (c) 2019 APA, all rights reserved).
本研究调查了慢性睡眠限制（CSR）对青春期大鼠即时和长期的认知影响。通过轻柔处理造成10天的慢性睡眠限制后，分别使用物体位置任务和物体识别任务测试了海马体依赖性和非海马体依赖性长期记忆能力。测试在青春期进行，并在4周的延迟期后进行，在此期间大鼠自由睡眠并发育至成年期。暴露于慢性睡眠限制的大鼠在青春期的物体位置任务上表现出记忆受损，这种受损持续到成年期。然而，慢性睡眠限制在两个时间点对物体识别任务的记忆均无影响。这些结果表明，青春期的慢性睡眠限制会导致海马体依赖性记忆受损，但不会影响非海马体依赖性记忆。此外，即使在4周不受干扰的睡眠后，这种损伤仍然存在。本研究是首个使用纵向研究方法来调查青春期慢性睡眠限制的啮齿动物模型，并为青少年健康提供了实际启示。（PsycINFO数据库记录（c）2019美国心理学会，保留所有权利）
