慢性睡眠中断的神经后果。
Neural consequences of chronic sleep disruption.
机构信息
Chronobiology and Sleep Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Chronobiology and Sleep Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
出版信息
Trends Neurosci. 2022 Sep;45(9):678-691. doi: 10.1016/j.tins.2022.05.007. Epub 2022 Jun 9.
Abstract
Recent studies in both humans and animal models call into question the completeness of recovery after chronic sleep disruption. Studies in humans have identified cognitive domains particularly vulnerable to delayed or incomplete recovery after chronic sleep disruption, including sustained vigilance and episodic memory. These findings, in turn, provide a focus for animal model studies to critically test the lasting impact of sleep loss on the brain. Here, we summarize the human response to sleep disruption and then discuss recent findings in animal models examining recovery responses in circuits pertinent to vigilance and memory. We then propose pathways of injury common to various forms of sleep disruption and consider the implications of this injury in aging and in neurodegenerative disorders.
摘要
最近在人类和动物模型中的研究对慢性睡眠中断后恢复的完全性提出了质疑。人类研究已经确定了在慢性睡眠中断后延迟或不完全恢复特别容易受到影响的认知领域，包括持续警觉和情景记忆。这些发现反过来为动物模型研究提供了重点，以批判性地测试睡眠不足对大脑的持久影响。在这里，我们总结了人类对睡眠中断的反应，然后讨论了最近在研究与警觉和记忆相关回路的恢复反应的动物模型中的发现。然后，我们提出了各种形式的睡眠中断共有的损伤途径，并考虑了这种损伤在衰老和神经退行性疾病中的意义。
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