Zhang Deguo, Tan Xueying, Tang Nan, Huang Fei, Chen Zengyin, Shi Guangjun
Department of Hepatobiliary Surgery, The Affiliated Qingdao Chengyang District People's Hospital of Qingdao University, Qingdao 266109, Shandong Province, People's Republic of China.
Department of Hepatobiliary Surgery, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao 266000, Shandong Province, People's Republic of China.
Onco Targets Ther. 2020 May 19;13:4423-4430. doi: 10.2147/OTT.S245178. eCollection 2020.
Irisin is a newly discovered exercise-induced cytokine, produced by the proteolytic hydrolysis of fibronectin type III domain-containing protein 5 (FNDC5). Irisin is widely distributed in the human body and is involved in the browning of white adipose tissue, improving insulin resistance, improving cognitive function, and regulating bone metabolism. Recent studies have shown that irisin concentration is elevated in a variety of tumor tissues as compared with that in normal tissues. However, irisin has different effects on the proliferation and apoptosis of tumor cells in breast cancer, lung cancer, and liver cancer through various mechanisms. Irisin plays an important role in the occurrence, development, and metastasis of different tumors, suggesting that irisin can be used as a potential target for tumor diagnosis and treatment. Therefore, studying the expression and function of irisin in tumors may be of great significance for the prevention and treatment of tumors. This article reviews the research progress on the role of irisin in tumors.
鸢尾素是一种新发现的运动诱导细胞因子，由含III型纤连蛋白结构域蛋白5（FNDC5）的蛋白水解产生。鸢尾素广泛分布于人体，参与白色脂肪组织的褐变、改善胰岛素抵抗、改善认知功能以及调节骨代谢。最近的研究表明，与正常组织相比，鸢尾素浓度在多种肿瘤组织中升高。然而，鸢尾素通过各种机制对乳腺癌、肺癌和肝癌中肿瘤细胞的增殖和凋亡有不同影响。鸢尾素在不同肿瘤的发生、发展和转移中起重要作用，这表明鸢尾素可作为肿瘤诊断和治疗的潜在靶点。因此，研究鸢尾素在肿瘤中的表达和功能可能对肿瘤的防治具有重要意义。本文综述了鸢尾素在肿瘤中作用的研究进展。
