Vermylen J, Blockmans D, Spitz B, Deckmyn H
Clin Haematol. 1986 May;15(2):393-412.
The purpose of this review has been to draw the attention of clinicians towards the possibility that some of the patients they are treating for thrombosis may have an underlying immune disturbance. This could involve functional abnormalities of the complement system (as in acquired angioneurotic oedema or in paroxysmal nocturnal haemoglobinuria), or cell-mediated immunological damage to the vessel wall (as in Behcet's syndrome or Buerger's disease), or the presence of circulating antibodies (the lupus anticoagulant or antibodies to heparin). While obviously our knowledge on most aspects is still very incomplete, the awareness of the association of thrombosis with certain immune disorders should encourage further detailed studies of mechanisms and enhance our understanding of the role of blood constituents and the vessel wall in thrombogenesis.
本综述的目的是提醒临床医生注意，他们正在治疗的一些血栓形成患者可能存在潜在的免疫紊乱。这可能涉及补体系统的功能异常（如在获得性血管性水肿或阵发性夜间血红蛋白尿中），或对血管壁的细胞介导免疫损伤（如在白塞病或血栓闭塞性脉管炎中），或存在循环抗体（狼疮抗凝物或抗肝素抗体）。虽然显然我们在大多数方面的知识仍然非常不完整，但认识到血栓形成与某些免疫疾病的关联应鼓励对机制进行进一步详细研究，并增强我们对血液成分和血管壁在血栓形成中作用的理解。
