Heldmann Marcus, Teichmann Sebastian, Al-Khaled Mohamed, Brüggemann Norbert, Münte Thomas F
Department of Neurology.
Institute of Psychology II, University of Lübeck, Lübeck, Germany.
Cogn Behav Neurol. 2019 Mar;32(1):31-38. doi: 10.1097/WNN.0000000000000185.
To investigate automatic auditory-change detection in patients with Parkinson disease (pwPD).
Previous results regarding changes in preattentive processing in pwPD have been inconclusive.
We employed a paradigm assessing the preattentive processing of sequences of auditory tones containing deviants at either the local or global level, or at both levels. Twenty pwPD and 20 age-matched healthy controls were exposed to the tone series while they performed a visual task and had their event-related potentials recorded by electroencephalogram.
Event-related potentials showed a mismatch negativity, which was largest for the double-deviant stimuli, of intermediate amplitude for the local deviant stimuli, and smallest for the global deviant stimuli. The mismatch negativity was of similar size in the patients and controls, with the exception of the double-deviant condition (larger in controls). By contrast, the subsequent positive component was more pronounced for the Parkinson disease group than controls, particularly for the double-deviant condition.
The larger positivity suggests that pwPD are more prone to distraction than healthy controls, probably because dopaminergic medication shifts the stability-flexibility balance toward cognitive flexibility with increased distractibility.
研究帕金森病患者（pwPD）的自动听觉变化检测能力。
先前关于pwPD前注意加工变化的结果尚无定论。
我们采用了一种范式，评估包含局部或全局层面或两个层面偏差的听觉音调序列的前注意加工。20名pwPD患者和20名年龄匹配的健康对照者在执行视觉任务时接受音调序列，并通过脑电图记录其事件相关电位。
事件相关电位显示出失匹配负波，双偏差刺激的失匹配负波最大，局部偏差刺激的失匹配负波幅度中等，全局偏差刺激的失匹配负波最小。除双偏差情况外（对照组更大），患者和对照组的失匹配负波大小相似。相比之下，帕金森病组的后续正成分比对照组更明显，尤其是在双偏差情况下。
更大的正性成分表明，pwPD比健康对照者更容易分心，可能是因为多巴胺能药物使稳定性 - 灵活性平衡向认知灵活性转移，导致分心增加。
