Abdelbasset Walid Kamal, Tantawy Sayed A, Kamel Dalia M, Alqahtani Bader A, Soliman Gaber S
Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Alkharj, Saudi Arabia.
Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
Medicine (Baltimore). 2019 Mar;98(12):e14918. doi: 10.1097/MD.0000000000014918.
Medications are limited for patients with nonalcoholic fatty liver disease (NAFLD). It has been reported that aerobic exercise is effective in reducing the characteristics of NAFLD, although unclear data have ascertained the effects of high-intensity interval aerobic exercise on health-related quality of life (HRQoL) in diabetic obese patients with NAFLD.
This a randomized controlled trial aimed to ascertain the effectiveness of 8-week high-intensity interval exercise on intrahepatic triglycerides (IHTG), visceral lipids and HRQoL in diabetic obese patients with NAFLD.
Between August and December 2017, 32 diabetic obese patients with NAFLD aged 45 to 60 years (21 men and 11 women) were enrolled in this study. They were randomly assigned to 2 groups, 16 patients in each group, high-intensity interval (HII) exercise and control groups. The HII group received a program of HII aerobic exercise for 8 weeks with medications of NAFLD and the control group received only medications without any type of exercise intervention. The test of IHTG, visceral lipids, and HRQoL were recorded at the initial assessment and at the end of the program after 8 weeks.
There were significant differences between the 2 groups at the end of the study. These study findings exhibited significant improvements in IHTG, VO2peak, visceral lipids, glycohemoglobin, plasma glucose, and all dimensions of HRQoL in the HII group (P <.05), But there was non-significant improvement in any measure in the control group (P >.05) after the 8-week intervention.
Eight-week high-intensity interval aerobic exercise has a beneficial effect on IHTG, visceral lipids, and HRQoL in diabetic obese patients with NAFLD. Effort and awareness should be dedicated to encouraging the active lifestyle among different population, especially diabetic obese patients with NAFLD.
非酒精性脂肪性肝病（NAFLD）患者的药物治疗有限。据报道，有氧运动对减轻NAFLD的特征有效，尽管尚无明确数据确定高强度间歇有氧运动对糖尿病肥胖NAFLD患者健康相关生活质量（HRQoL）的影响。
本随机对照试验旨在确定为期8周的高强度间歇运动对糖尿病肥胖NAFLD患者肝内甘油三酯（IHTG）、内脏脂肪和HRQoL的有效性。
2017年8月至12月，32名年龄在45至60岁之间的糖尿病肥胖NAFLD患者（21名男性和11名女性）纳入本研究。他们被随机分为2组，每组16名患者，即高强度间歇（HII）运动组和对照组。HII组接受为期8周的HII有氧运动方案并服用NAFLD药物，对照组仅服用药物，不进行任何运动干预。在初始评估时以及8周方案结束时记录IHTG、内脏脂肪和HRQoL测试结果。
研究结束时两组之间存在显著差异。这些研究结果显示，HII组的IHTG、最大摄氧量（VO2peak）、内脏脂肪、糖化血红蛋白、血糖和HRQoL的所有维度均有显著改善（P<0.05），但8周干预后对照组的任何指标均无显著改善（P>0.05）。
为期8周的高强度间歇有氧运动对糖尿病肥胖NAFLD患者的IHTG、内脏脂肪和HRQoL有有益影响。应努力并提高认识，鼓励不同人群，尤其是糖尿病肥胖NAFLD患者保持积极的生活方式。
