Inhibition of nocturnal gastric secretion by trimoprostil, a synthetic prostanoid.
作者信息
Penston J, Johnston D A, Wilson J A, Wormsley K G
出版信息
Curr Med Res Opin. 1986;10(3):145-9. doi: 10.1185/03007998609110433.
PMID:3089691
Abstract
Eleven healthy volunteers had nocturnal gastric secretion studied on three occasions to compare, in a randomized manner, the gastric inhibitory effects of two doses (1.5 and 3.0 mg) of trimoprostil with placebo. Nocturnal gastric secretion of acid was significantly inhibited for 7 hours with the higher dose of the drug, by a total of about 50 percent. The output of pepsin was also reduced, albeit not as markedly as acid, for the first 5 hours of the study. It is concluded that trimoprostil, in the doses used in the present study, is capable of reducing gastric secretion without producing side-effects.
摘要
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