a Department of Vascular Surgery , Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , Nanjing , People's Republic of China.
b School of Chemistry and National and Local Joint Engineering Research Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Biofunctional Materials Materials Science , Nanjing Normal University , Nanjing , People's Republic of China.
J Biomater Sci Polym Ed. 2019 May;30(7):547-560. doi: 10.1080/09205063.2019.1586303. Epub 2019 Apr 7.
Bioresorbable vascular scaffolds are expected to replace the traditional metal stent, avoiding the long-term complications of metal stents. However, it is hard for the traditional scaffold manufacturing process to meet the requirements of individualized treatment for vascular lesions, which requires different morphologies. Here, we used a new method of scaffold manufacturing, three-dimensional printing technology, to prepare bioresorbable vascular scaffolds. The fabricated scaffold was loaded with sirolimus mixed with scaffold preparation material for slow drug release. The engineered, drug- loaded, bioresorbable vascular scaffold (BVS) was analyzed and tested in vivo. The scaffolds produced by three-dimensional printing technology exhibited good mechanical properties and in vitro degradation performance. The results also suggested that these scaffolds could maintain effective radial strength after long-term degradation and sustained release of the drug. As a new scaffold preparation method, it may provide a promising idea for developing bioresorbable vascular scaffold technology.
生物可吸收血管支架有望替代传统的金属支架，避免金属支架带来的长期并发症。然而，传统的支架制造工艺很难满足血管病变的个体化治疗要求，需要不同的形态。在这里，我们使用了一种新的支架制造方法，即三维打印技术，来制备生物可吸收血管支架。所制备的支架负载有与支架制备材料混合的西罗莫司，用于药物的缓慢释放。对工程化、载药、生物可吸收血管支架（BVS）进行了体内分析和测试。三维打印技术制备的支架表现出良好的机械性能和体外降解性能。结果还表明，这些支架在药物的长期降解和持续释放后仍能保持有效的径向强度。作为一种新的支架制备方法，它可能为开发生物可吸收血管支架技术提供了一个有前途的思路。
