Changes in Brain Volume Associated With Vegetable Intake in a General Population.

Although brain atrophy is a natural process of healthy aging, diet may play a role in delaying the process across age. We sought to investigate how food groups associate brain region-specific volume changes over 4 years in a general population. We obtained data from the Korean Genome and Epidemiology Study on 848 community-dwelling individuals. The participants completed a dietary examination using a food frequency questionnaire between 2005 and 2006 to determine habitual usual intakes of food consumption and two brain magnetic resonance imaging (MRI) scans between 2011 and 2014 and between 2015 and 2017, respectively. The 106 food items in the questionnaire were regrouped into 18 food groups. A multivariable generalized linear model was used with the adjustment of potential confounding variables. The average age at baseline was 53.5 years. The average follow-up year of brain MRI was 4.13 ± 0.33 years. With considering a corrected value due to multiple comparisons, vegetable intake indicated a statistically significant inverse association with gray matter volume change (β = -2.28,  = 0.006), after adjusting for potential confounding variables. Particularly, the temporal region showed a significant inverse association with vegetable intake (β= -0.63,  = 0.002). In a longitudinal study among 848 cognitively healthy participants from a general population, we found significant inverse associations between vegetable intake and brain gray matter volume change, particularly the change of temporal region.