Schwärzer Kuno, Bellan Andreas, Zöschg Maximilian, Karaghiosoff Konstantin, Knochel Paul
Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstraße 5-13, Haus F, 81377, München, Germany.
Chemistry. 2019 Jul 17;25(40):9415-9418. doi: 10.1002/chem.201900903. Epub 2019 Apr 29.
The selective addition of organomagnesium reagents to 2,4,6-trichlorophenyl isocyanide leading to magnesiated aldimines is reported. These aldimines react with Weinreb amides, ketones, or carbonates to provide the corresponding carbonyl derivatives after acidic cleavage. This allows for an efficient synthesis of 1,2-dicarbonyl compounds and α-hydroxy ketones.
据报道，有机镁试剂选择性加成到2,4,6-三氯苯基异氰化物上可生成镁化醛亚胺。这些醛亚胺与温瑞布酰胺、酮或碳酸酯反应，经酸解后得到相应的羰基衍生物。这使得1,2-二羰基化合物和α-羟基酮的高效合成成为可能。
