Aporphine alkaloids with antiplasmodial activity from the leaves of .

One new aporphine named tavoyanine A (), along with four known aporphines laetanine (), roemerine (), laurolitsine (), and boldine (), and one morphinandienone type sebiferine () were isolated from the leaves of (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (), laurolitsine (), boldine (), and sebiferine (). The results showed that - have a potent inhibitory activity against the growth of 3D7 clone, with IC values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively.