Omar Hanita, Fadaeinasab Mehran, Taha Hairin, Widyawaruyanti Aty, Nafiah Mohd Azlan, Rachmatiah Tiah
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
Centre for Foundation Studies in Science, University of Malaya, Kuala Lumpur 50603, Malaysia.
J Asian Nat Prod Res. 2020 Jan;22(1):52-60. doi: 10.1080/10286020.2018.1553958. Epub 2019 Mar 21.
One new aporphine named tavoyanine A (), along with four known aporphines laetanine (), roemerine (), laurolitsine (), and boldine (), and one morphinandienone type sebiferine () were isolated from the leaves of (Meissn.) Hook f. (Lauraceae). The isolation was achieved by chromatographic techniques, and the structural elucidation was performed via spectral methods. This paper also reports the antiplasmodial activity of roemerine (), laurolitsine (), boldine (), and sebiferine (). The results showed that - have a potent inhibitory activity against the growth of 3D7 clone, with IC values of 0.89, 1.49, 1.65, and 2.76 µg/ml, respectively.
从（樟科）的叶中分离出一种新的阿朴啡碱，命名为塔沃宁碱A（），以及四种已知的阿朴啡碱，即拉坦宁碱（）、罗默碱（）、月桂利辛碱（）和波尔定碱（），还有一种吗啡二烯酮型的塞比费林碱（）。通过色谱技术进行分离，并通过光谱方法进行结构解析。本文还报道了罗默碱（）、月桂利辛碱（）、波尔定碱（）和塞比费林碱（）的抗疟活性。结果表明，对3D7克隆的生长具有较强的抑制活性，IC值分别为0.89、1.49、1.65和2.76µg/ml。
