消炎痛、前列腺素E2和I2对人离体股动脉张力的影响。
Effects of indomethacin, prostaglandins E2 and I2 on the tone of human isolated femoral arteries.
作者信息
Hadházy P, Nagy L, Dömötör L, Magyar K
出版信息
Eur J Clin Invest. 1986 Jun;16(3):248-51. doi: 10.1111/j.1365-2362.1986.tb01337.x.
Strips of endothelium-denuded femoral arteries from operated patients were set up for isometric recording. Indomethacin (IND, 3 mumol 1(-1] enhanced basal tension of the arteries from 0.13 +/- 0.04 to 0.86 +/- 0.12 mN (P less than 0.001; n = 16) and potentiated the contractile responses of the strips to noradrenaline (NA); EC50 for NA was 1.5 +/- 0.3 mumol 1(-1) (n = 6) in the absence, and 0.4 +/- 0.07 mumol 1(-1) (n = 6) in the presence of IND (P less than 0.01). PGI2 produced dose-related relaxation in IND-treated vessels, its IC50 being 15.0 +/- 1.3 nmol 1(-1). Low concentrations of PGE2 (0.85-8.5 nmol 1(-1] reduced whereas its higher concentrations (28-85 nmol 1(-1] increased smooth muscle tone in the presence of IND. These results indicate that human femoral arteries--unlike femoral arteries of some laboratory animals--are highly sensitive to cyclooxygenase inhibition as well as to PGI2 and PGE2.
将手术患者的去内皮股动脉条进行等长记录。吲哚美辛（IND，3 μmol·L⁻¹）使动脉的基础张力从0.13±0.04 mN增强至0.86±0.12 mN（P<0.001；n = 16），并增强了动脉条对去甲肾上腺素（NA）的收缩反应；在不存在IND时，NA的半数有效浓度（EC50）为1.5±0.3 μmol·L⁻¹（n = 6），在存在IND时为0.4±0.07 μmol·L⁻¹（n = 6）（P<0.01）。前列环素（PGI2）在IND处理的血管中产生剂量相关的舒张作用，其半数抑制浓度（IC50）为15.0±1.3 nmol·L⁻¹。在存在IND的情况下，低浓度的前列腺素E2（PGE2，0.85 - 8.5 nmol·L⁻¹）降低平滑肌张力，而其高浓度（28 - 85 nmol·L⁻¹）则增加平滑肌张力。这些结果表明，与一些实验动物的股动脉不同，人类股动脉对环氧合酶抑制以及PGI2和PGE2高度敏感。
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