Coelho J C, Gouma D J, Moody F G, Li Y F, Weisbrodt N W
Eur J Clin Invest. 1986 Jun;16(3):252-6. doi: 10.1111/j.1365-2362.1986.tb01338.x.
The effect of serotonin on the myoelectric activity of the gastrointestinal tract was evaluated in seven opossums. Continuous intravenous administration of serotonin reduced the cycle duration of the migrating myoelectric complex and increased the velocity of propagation of the phase III. These changes were dose-dependent and were observed only with high doses of serotonin of 0.1 mg kg-1 h-1 or more. Infusion of 0.01 mg kd-1 h-1 had no effect on the motility of the gastrointestinal tract. The motility changes occurred in all segments of the gastrointestinal tract studied and were characterized by a continuous and organized increase in the velocity of propagation of the activity front (phase III) of the migrating myoelectric complex from the antrum to the terminal ileum. The cycle duration of the two migrating myoelectric complexes following administration of methysergide at 1.0 mg kg-1 was similar to the control migrating myoelectric complexes. We concluded that continuous infusion of serotonin in the opossum increases the velocity of propagation of the phase III of the migrating myoelectric complex from the antrum to the terminal ileum.
在七只负鼠身上评估了血清素对胃肠道肌电活动的影响。持续静脉注射血清素可缩短移行性肌电复合波的周期时长，并提高Ⅲ期的传播速度。这些变化具有剂量依赖性，且仅在血清素剂量达到0.1毫克/千克·小时或更高时才会出现。输注0.01毫克/千克·小时对胃肠道蠕动没有影响。在所有研究的胃肠道节段均出现了蠕动变化，其特征是移行性肌电复合波活动前沿（Ⅲ期）从胃窦到回肠末端的传播速度持续且有规律地增加。在给予1.0毫克/千克的甲基麦角新碱后，两个移行性肌电复合波的周期时长与对照移行性肌电复合波相似。我们得出结论，在负鼠体内持续输注血清素会增加移行性肌电复合波Ⅲ期从胃窦到回肠末端的传播速度。
