Wechsung E, Houvenaghel A
Laboratory of Veterinary Physiology, University Centre of Antwerp, Belgium.
Zentralbl Veterinarmed A. 1994 Aug;41(6):459-65. doi: 10.1111/j.1439-0442.1994.tb00112.x.
In conscious piglets provided chronically with electrodes in the wall of the antrum pylori, duodenum, jejunum and ileum, the effect of intravenous infusion of 5-HT, 4 micrograms/kg/min for 2 h, with and without pre-treatment with atropine, 0.5 mg/kg, on gastrointestinal myoelectrical activity was studied. In the antrum, fast oscillations were partially inhibited by 5-HT and nearly completely blocked by the atropine/5-HT combination and by atropine alone. In the small intestine 5-HT induced a decrease in MMC interval, an increase in phase III activity in duodenum and jejunum and an acceleration of propagation velocity as measured for the jejunum. These effects were not influenced by atropine. Following atropine, phase II activity in the jejunum was significantly inhibited by 5-HT. The ileum was rather insensitive to 5-HT. It is concluded that the inhibitory effect of 5-HT on antral electrical activity is enhanced by atropine, and that 5-HT has a stimulatory effect on small intestinal activity which is not dependent on a muscarinic action.
在长期在幽门窦、十二指肠、空肠和回肠壁植入电极的清醒仔猪中，研究了静脉输注5-羟色胺（5-HT）（4微克/千克/分钟，持续2小时），以及在有或没有预先给予0.5毫克/千克阿托品的情况下，对胃肠肌电活动的影响。在胃窦，快速振荡被5-HT部分抑制，几乎完全被阿托品/5-HT组合和单独的阿托品阻断。在小肠，5-HT导致移行性复合运动（MMC）间隔缩短，十二指肠和空肠的Ⅲ期活动增加，空肠的传播速度加快。这些作用不受阿托品影响。给予阿托品后，5-HT显著抑制空肠的Ⅱ期活动。回肠对5-HT相当不敏感。得出的结论是，阿托品增强了5-HT对胃窦电活动的抑制作用，并且5-HT对小肠活动有刺激作用，这种作用不依赖于毒蕈碱作用。
