Martínez V, Jiménez M, Gońalons E, Vergara P
Department of Cell Biology and Physiology, Veterinary Faculty, Universitat Autònoma de Barcelona, Spain.
Am J Physiol. 1995 Aug;269(2 Pt 2):R445-52. doi: 10.1152/ajpregu.1995.269.2.R445.
Infusion of lipids into the ileum delays gastric emptying and intestinal transit time in some species. The aim of this study was to characterize the actions of intraluminal lipid infusion on gastrointestinal electrical activity in chickens. Animals were prepared for electromyography with chronic electrodes in stomach, duodenum, and small intestine. Two catheters were chronically placed in the esophagus and ileum to infuse equimolar doses of either oleic acid (OA) or triolein (TO). Both OA and TO, esophageally infused, inhibited the frequency of the gastroduodenal cycle and increased the frequency of antiperistaltic spike bursts in the duodenum. Ileal infusion of OA, but not of TO, produced the same effects. Both esophageal and ileal OA infusion increased the duration of the migrating myoelectric complex (MMC) and decreased the speed of propagation of phase III. In conclusion, intraluminal infusion of lipids modulates gastrointestinal motility by decreasing the frequency of the gastric cycle, increasing duodenogastric refluxes, and elongating the MMC. These actions could delay gastric emptying and increase transit time, which suggests the presence of an "ileal brake" mechanism similar to that described in mammals.
在某些物种中，向回肠输注脂质会延迟胃排空和肠道传输时间。本研究的目的是描述腔内脂质输注对鸡胃肠道电活动的作用。用慢性电极在胃、十二指肠和小肠为动物准备肌电图检查。两根导管长期置于食管和回肠，以输注等摩尔剂量的油酸（OA）或三油酸甘油酯（TO）。食管内输注OA和TO均抑制胃十二指肠周期频率，并增加十二指肠逆蠕动尖峰爆发的频率。回肠输注OA而非TO产生相同效果。食管和回肠输注OA均增加移行性肌电复合波（MMC）的持续时间，并降低III期传播速度。总之，腔内输注脂质通过降低胃周期频率、增加十二指肠胃反流和延长MMC来调节胃肠动力。这些作用可能延迟胃排空并增加传输时间，这表明存在类似于哺乳动物中描述的“回肠制动”机制。
