State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 210009, China.
State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University, Nanjing 210009, China.
Bioorg Med Chem Lett. 2019 May 15;29(10):1236-1240. doi: 10.1016/j.bmcl.2019.03.007. Epub 2019 Mar 6.
Lipase RMIM was firstly used as a promiscuous biocatalyst to catalyze the Knoevenagel-Michael cascade reactions of 4-hydroxycoumarin with aromatic, heterocyclic or aliphatic aldehydes to synthesize dicoumarol derivatives in water. Results showed that the adopted methodology could offer many advantages, such as mild reaction conditions, pure aqueous reaction system, wide substrate applicability, recyclable catalyst, excellent yields (81-98%), operational simplicity, and environmentally friendly reactions.
脂肪酶 RMIM 首先被用作一种多功能生物催化剂，用于催化 4-羟基香豆素与芳香醛、杂环醛或脂肪醛的 Knoevenagel-Michael 级联反应，在水中合成二香豆素衍生物。结果表明，所采用的方法具有许多优点，如温和的反应条件、纯水性反应体系、广泛的底物适用性、可回收的催化剂、优异的产率（81-98%）、操作简单和环境友好的反应。
