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在纯水中通过酶法级联合成双（吲哚基）甲烷。

Enzymatic approach to cascade synthesis of bis(indolyl)methanes in pure water.

作者信息

Fu Yajie, Lu Zeping, Fang Ke, He Xinyi, Xu Huajin, Hu Yi

机构信息

State Key Laboratory of Materials-Oriented Chemical Engineering, School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 210009 China

出版信息

RSC Adv. 2020 Mar 16;10(18):10848-10853. doi: 10.1039/c9ra10014h. eCollection 2020 Mar 11.

DOI:10.1039/c9ra10014h
PMID:35492907
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9050360/
Abstract

A mild, efficient, and green protocol was developed for the synthesis of bis(indolyl)methanes catalyzed by lipase TLIM through the cascade reactions of indole with aldehydes in pure water. This methodology offers many superiorities such as excellent yields, wide substrate range, simple procedure, reusable and minimal amount of catalyst, and the ability to be scaled up.

摘要

开发了一种温和、高效且绿色的方法，用于在纯水中通过脂肪酶TLIM催化吲哚与醛的级联反应合成双（吲哚基）甲烷。该方法具有许多优点，如产率高、底物范围广、操作简单、催化剂可重复使用且用量少，以及能够扩大规模。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/e692738b0408/c9ra10014h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/d900ca97cd77/c9ra10014h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/b636569c2800/c9ra10014h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/f570684fa340/c9ra10014h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/e692738b0408/c9ra10014h-s3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/d900ca97cd77/c9ra10014h-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/b636569c2800/c9ra10014h-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/f570684fa340/c9ra10014h-s2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae61/9050360/e692738b0408/c9ra10014h-s3.jpg

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Diindolylmethane Derivatives: Potent Agonists of the Immunostimulatory Orphan G Protein-Coupled Receptor GPR84.
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Efficient Green Synthesis, Anticancer Activity, and Molecular Docking Studies of Indolemethanes Using a Bioglycerol-Based Carbon Sulfonic Acid Catalyst.基于生物甘油的碳磺酸催化剂用于吲哚甲烷的高效绿色合成、抗癌活性及分子对接研究
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