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年龄对辅助使用丝裂霉素C的准分子激光上皮下角膜磨镶术（LASEK）后视力和屈光结果的影响。

Effect of age on visual and refractive results after laser-assisted subepithelial keratomileusis (LASEK) with adjuvant use of mitomycin C.

作者信息

Garcia-Gonzalez Montserrat, Gros-Otero Juan, Rodriguez-Perez Isabel, Rodero Alberto, Teus Miguel A

机构信息

Clínica Novovisión Madrid, Madrid, Spain; Clínica Rementería, Madrid, Spain.

Clínica Rementería, Madrid, Spain.

出版信息

J Optom. 2019 Apr-Jun;12(2):92-98. doi: 10.1016/j.optom.2019.01.001. Epub 2019 Mar 18.

DOI:10.1016/j.optom.2019.01.001
PMID:30898533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6449780/
Abstract

PURPOSE

To evaluate the influence of age on visual and refractive results after laser-assisted subepithelial keratomileusis (LASEK) with the adjuvant use of mitomycin C (MMC) for the correction of myopia.

METHODS

Retrospective, nonrandomized, cohort study. A total of 1374 eyes treated with LASEK+MMC were included in the study (we compared 1163 eyes of patients aged 18 to 40 years versus 211 eyes of patients over 40 years). Visual and refractive results were evaluated at the 6-month postoperative visit.

RESULTS

Six months postoperatively, both the uncorrected distance visual acuity and the corrected distance visual acuity were significantly better in the group of young patients (P=0.0001). We found a slight tendency to overcorrection in the group of young patients compared to a slight tendency to undercorrection in the group of patients over 40 years (P=0.002). The efficacy index was significantly better in the group of younger patients (0.91±0.2) than in the older patients (0.86±0.2) (P=0.0001). No significant difference was found in the safety index between groups. 81.5% of eyes in the group of patients aged 18 to 40 years compared to 75.3% of eyes in the group of patients aged >40 years were within±0.5D of emmetropia (P=0.001).

CONCLUSIONS

A tendency toward undercorrection and less predictability was found with aging after myopic LASEK with MMC for the correction of myopia.

摘要

目的

评估年龄对使用丝裂霉素C（MMC）辅助的准分子激光上皮下角膜磨镶术（LASEK）矫正近视后视觉和屈光结果的影响。

方法

回顾性、非随机队列研究。本研究共纳入1374只接受LASEK+MMC治疗的眼睛（我们比较了1163只年龄在18至40岁患者的眼睛与211只40岁以上患者的眼睛）。在术后6个月随访时评估视觉和屈光结果。

结果

术后6个月，年轻患者组的未矫正远视力和矫正远视力均显著更好（P=0.0001）。我们发现年轻患者组有轻微的过矫正倾向，而40岁以上患者组有轻微的欠矫正倾向（P=0.002）。年轻患者组的疗效指数（0.91±0.2）显著优于老年患者组（0.86±0.2）（P=0.0001）。两组间安全指数无显著差异。18至40岁患者组中81.5%的眼睛与年龄>40岁患者组中75.3%的眼睛屈光不正度数在正视眼±0.5D范围内（P=0.001）。

结论

对于近视LASEK联合MMC矫正近视，随着年龄增长存在欠矫正倾向且可预测性降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/d266f259573d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/5cff2f2e249f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/e07b2fe45178/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/d266f259573d/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/5cff2f2e249f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/e07b2fe45178/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33fb/6449780/d266f259573d/gr3.jpg

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