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避孕激素的哺乳期影响:一项评估(LECHE)研究。

The Lactational Effects of Contraceptive Hormones: an Evaluation (LECHE) Study.

机构信息

University of North Carolina School of Medicine, Department of Obstetrics and Gynecology, Division of Family Planning, Gillings School of Public Health Department of Maternal and Child Health.

University of North Carolina School of Medicine, Department of Psychiatry, UNC Center for Women's Mood Disorders.

出版信息

Contraception. 2019 Jul;100(1):48-53. doi: 10.1016/j.contraception.2019.03.040. Epub 2019 Mar 18.

Abstract

OBJECTIVE

To estimate the proportion of women for whom use of hormonal contraception was associated with reporting a decreased breast milk supply.

STUDY DESIGN

The Lactational Effects of Contraceptive Hormones: an Evaluation ("LECHE") Study was an anonymous, internet-based, exploratory, cross-sectional survey of postpartum women using approximately 70 questions. Women were eligible to participate in the survey if they were 18 years or older, had a singleton infant between 3 and 9 months of age, had breastfed this infant for any amount of time and could read English. The survey included questions about breastfeeding, reproductive health, demographic characteristics and the timing of postpartum events.

RESULTS

A total of 3971 participants clicked on the survey. Our final study population included 2922 participants. Overall, 1201 (41%) reported having had milk supply concerns at some point in the first 12 weeks postpartum. The median time from birth until milk supply concerns was 3 weeks (IQR 1-7). Eight hundred fifty-two women (29%) started hormonal contraception in the first 12 weeks postpartum. Fifteen percent (127/852) of women reported new or additional milk supply concerns after starting hormonal contraception. Reported milk supply concerns were higher for women who used hormonal contraception than those who did not (44% vs. 40%; p=.05) Adjusted hazard ratios (HRs) assessing the association between contraceptive use and time to milk supply concerns were not statistically significant (HR 1.18, 95% confidence interval 0.94-1.47 for any type of hormonal contraception).

CONCLUSIONS

This study found a slightly increased proportion of reported milk supply concerns among women who started hormonal contraception.

IMPLICATIONS

It is important for caregivers in the postpartum period to recognize the potential for multiple factors, including initiation of hormonal contraception, to affect breastfeeding. Patient-centered counseling can help elicit women's values and preferences regarding breastfeeding and pregnancy prevention.

摘要

目的

评估因使用激素避孕而报告母乳供应减少的女性比例。

研究设计

避孕激素对哺乳的影响:一项评估(“LECHE”)研究是一项基于互联网的匿名、探索性、横断面调查,调查对象为产后使用大约 70 个问题的女性。如果女性年龄在 18 岁或以上,有一个 3 至 9 个月大的单胎婴儿,曾母乳喂养过该婴儿,并且能阅读英语,就有资格参加调查。该调查包括关于母乳喂养、生殖健康、人口统计学特征和产后事件时间的问题。

结果

共有 3971 名参与者点击了调查。我们的最终研究人群包括 2922 名参与者。总体而言,1201 名(41%)报告在产后前 12 周的某个时候有过母乳供应问题。从出生到出现母乳供应问题的中位数时间为 3 周(IQR 1-7)。852 名女性(29%)在产后 12 周内开始使用激素避孕。15%(127/852)在开始使用激素避孕后报告新的或额外的母乳供应问题。使用激素避孕的女性报告母乳供应问题的比例高于未使用激素避孕的女性(44% vs. 40%;p=.05)。评估避孕使用与母乳供应问题时间之间关联的调整后的风险比(HR)无统计学意义(任何类型的激素避孕的 HR 为 1.18,95%置信区间 0.94-1.47)。

结论

本研究发现,开始使用激素避孕的女性报告母乳供应问题的比例略有增加。

意义

在产后期间,护理人员应认识到多种因素(包括开始使用激素避孕)可能会影响母乳喂养,这一点很重要。以患者为中心的咨询可以帮助了解女性在母乳喂养和妊娠预防方面的价值观和偏好。

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