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Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions.

作者信息

Meyer Claus, Lopes Bruno A, Caye-Eude Aurélie, Cavé Hélène, Arfeuille Chloé, Cuccuini Wendy, Sutton Rosemary, Venn Nicola C, Oh Seung Hwan, Tsaur Grigory, Escherich Gabriele, Feuchtinger Tobias, Kosasih Hansen J, Khaw Seong L, Ekert Paul G, Pombo-de-Oliveira Maria S, Bidet Audrey, Djahanschiri Bardya, Ebersberger Ingo, Zaliova Marketa, Zuna Jan, Zermanova Zuzana, Juvonen Vesa, Grümayer Renate Panzer, Fazio Grazia, Cazzaniga Gianni, Larghero Patrizia, Emerenciano Mariana, Marschalek Rolf

机构信息

DCAL/Institute of Pharmaceutical Biology, Goethe-University Frankfurt, Frankfurt am Main, Germany.

Division of Clinical Research, Research Center, Instituto Nacional de Cancer, Rio de Janeiro, Brazil.

出版信息

Leukemia. 2019 Sep;33(9):2306-2340. doi: 10.1038/s41375-019-0451-7. Epub 2019 Mar 21.

DOI:10.1038/s41375-019-0451-7
PMID:30899083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6756029/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0e/6756029/eb42520e7b6a/41375_2019_451_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0e/6756029/7061ac48332d/41375_2019_451_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0e/6756029/eb42520e7b6a/41375_2019_451_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0e/6756029/7061ac48332d/41375_2019_451_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3c0e/6756029/eb42520e7b6a/41375_2019_451_Fig2_HTML.jpg

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本文引用的文献

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The genetic basis and cell of origin of mixed phenotype acute leukaemia.混合表型急性白血病的遗传基础和细胞起源。
Nature. 2018 Oct;562(7727):373-379. doi: 10.1038/s41586-018-0436-0. Epub 2018 Sep 12.
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KMT2A (MLL) rearrangements observed in pediatric/young adult T-lymphoblastic leukemia/lymphoma: A 10-year review from a single cytogenetic laboratory.儿童/青年 T 淋巴细胞白血病/淋巴瘤中观察到的 KMT2A(MLL)重排:来自单个细胞遗传学实验室的 10 年回顾。
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The MLL recombinome of acute leukemias in 2017.
一名急性单核细胞白血病患者中因插入导致的隐匿性融合
Genes (Basel). 2025 Mar 7;16(3):317. doi: 10.3390/genes16030317.
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Unveiling the Complexity of Rearrangements in Acute Myeloid Leukemias with Optical Genome Mapping.利用光学基因组图谱揭示急性髓系白血病重排的复杂性
Cancers (Basel). 2024 Dec 14;16(24):4171. doi: 10.3390/cancers16244171.
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Real-World Clinical Utility of Targeted RNA Sequencing in Leukemia Diagnosis and Management.靶向RNA测序在白血病诊断和管理中的真实世界临床应用
Cancers (Basel). 2024 Jul 5;16(13):2467. doi: 10.3390/cancers16132467.
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Genomic DNA-based measurable residual disease monitoring in pediatric acute myeloid leukemia: unselected consecutive cohort study.基于基因组 DNA 的小儿急性髓系白血病可测量残留病监测:未经选择的连续队列研究。
Leukemia. 2024 Jan;38(1):21-30. doi: 10.1038/s41375-023-02083-9. Epub 2023 Nov 24.
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Oncol Rep. 2023 Oct;50(4). doi: 10.3892/or.2023.8613. Epub 2023 Aug 18.
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Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity.对去泛素化酶在维持基因组完整性中的作用进行系统表征。
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Deubiquitylases from genes to organism.从基因到生物体的去泛素化酶。
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